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Author Details

John F Hunt
Columbia University
1986
116
47
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37398404Comparative genetic, biochemical, and biophysical analyses of the four <i>E. coli</i> ABCF paralogs support distinct functions related to mRNA translation.bioRxiv2023
34793198Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.Science2022
35801308Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.EMBO J2022
33135152ABC-F translation factors: from antibiotic resistance to immune response.FEBS Lett2021
33895137ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis.J Biol Chem2021
33720715Stability Prediction for Mutations in the Cytosolic Domains of Cystic Fibrosis Transmembrane Conductance Regulator.J Chem Inf Model2021
31759907CFTR: New insights into structure and function and implications for modulation by small molecules.J Cyst Fibros2020
31665817Evolutionary coupling saturation mutagenesis: Coevolution-guided identification of distant sites influencing Bacillus naganoensis pullulanase activity.FEBS Lett2020
31794207High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application.J Am Chem Soc2020
30484965The new strategies to overcome challenges in protein production in bacteria.Microb Biotechnol2019
31436959Structural Basis by Which the N-Terminal Polypeptide Segment of <i>Rhizopus chinensis</i> Lipase Regulates Its Substrate Binding Affinity.Biochemistry2019
31563533ABC-F proteins in mRNA translation and antibiotic resistance.Res Microbiol2019
29903914Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.J Biol Chem2018
28731268<sup>13</sup> C metabolic flux profiling of Pichia pastoris grown in aerobic batch cultures on glucose revealed high relative anabolic use of TCA cycle and limited incorporation of provided precursors of branched-chain amino acids.FEBS J2017
28125789Codon Clarity or Conundrum?Cell Syst2017
26760206Codon influence on protein expression in E. coli correlates with mRNA levels.Nature2016
26293815A community resource of experimental data for NMR / X-ray crystal structure pairs.Protein Sci2016
27294475Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.ACS Chem Biol2016
25451037A general computational approach for repeat protein design.J Mol Biol2015
26650357Precise assembly of complex beta sheet topologies from de novo designed building blocks.Elife2015
24161950Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.J Mol Biol2014
24971458Comparing chemistry to outcome: the development of a chemical distance metric, coupled with clustering and hierarchal visualization applied to macromolecular crystallography.PLoS One2014
25043760Protein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkB.J Biol Chem2014
25014715Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine.Biochem J2014
24911101Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family.ACS Chem Biol2014
24705591Design of activated serine-containing catalytic triads with atomic-level accuracy.Nat Chem Biol2014
24652590Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains.Protein Sci2014
24389465EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics.Nat Struct Mol Biol2014
24389466The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.Nat Struct Mol Biol2014
23330600Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction.ACS Chem Biol2013
24215428Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatus.Biochemistry2013
23827138Computational design of a protein-based enzyme inhibitor.J Mol Biol2013
23851074Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins.FEBS Lett2013
23378596Cystic fibrosis transmembrane conductance regulator (ABCC7) structure.Cold Spring Harb Perspect Med2013
23542644Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.Nat Chem Biol2013
23167435ATPase active-site electrostatic interactions control the global conformation of the 100 kDa SecA translocase.J Am Chem Soc2013
22178611The methylthiolation reaction mediated by the Radical-SAM enzymes.Biochim Biophys Acta2012
23013770Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage.Biol Direct2012
22740688The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography.J Biol Chem2012
22876860Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations.Biochemistry2012
22843345Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product.J Struct Funct Genomics2012
22871159Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.J Am Chem Soc2012
22065580Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.J Biol Chem2012
22133431The structure and enzymatic properties of a novel RNase II family enzyme from Deinococcus radiodurans.J Mol Biol2012
21153711Solution NMR and X-ray crystal structures of membrane-associated Lipoprotein-17 domain reveal a novel fold.J Struct Funct Genomics2011
22587847Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli.Microb Inform Exp2011
22049338Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.Proc Natl Acad Sci U S A2011
22020785Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction.Proteins2011
21719796Physiological response to membrane protein overexpression in E. coli.Mol Cell Proteomics2011
20007320Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase.J Biol Chem2010
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Collaborators

Gaetano T Montelione
Rensselaer Polytechnic Institute
Co-authored papers 39
Rong Xiao
School of Public Health, Capital Medical University
Co-authored papers 25
Thomas B Acton
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Co-authored papers 20
Sergey M Vorobiev
Columbia University
Co-authored papers 10
Liang Tong
Columbia University
Co-authored papers 9
Burkhard Rost
Technical University of Munich (TUM)
Co-authored papers 8
David Baker
University of Washington
Co-authored papers 8
Xun Zhao
Co-authored papers 6
Michael A Kennedy
Miami University
Co-authored papers 5
J S Emtage
Co-authored papers 5
John J Fak
Co-authored papers 4
Li-Chung Ma
Robert Wood Johnson Medical School, The State University of New Jersey
Co-authored papers 4
Shane Atwell
Lilly Research Laboratories
Co-authored papers 4
J Michael Sauder
Eli Lilly and Co.
Co-authored papers 4
Val??rie de Cr??cy-Lagard
University of Florida
Co-authored papers 4
Masayori Inouye
Robert Wood Johnson Medical School, Rutgers University
Co-authored papers 4
Marco Punta
Co-authored papers 3
Yuanpeng J Huang
Center for Advanced Biotechnology and Medicine, The State University of New Jersey
Co-authored papers 3
Haleema Janjua
Center for Advanced Biotechnology and Medicine, The State University of New Jersey
Co-authored papers 3
Wayne A Hendrickson
Columbia University
Co-authored papers 3
Ritu Shastry
Co-authored papers 3
Stephen K Burley
The State University of New Jersey
Co-authored papers 2
Frances Lu
Co-authored papers 2
Joachim Frank
Columbia University
Co-authored papers 2
Barry Honig
Columbia University Irving Medical Center
Co-authored papers 2
Patrick R Griffin
The Scripps Research Institute
Co-authored papers 2
Andrzej Joachimiak
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 2
Chi Kent Ho
Co-authored papers 2
Kristin C Gunsalus
Center for Genomics and Systems Biology, New York University Abu Dhabi (NYUAD)
Co-authored papers 2
Lawrence Shapiro
Zuckerman Mind Brain Behaviour Institute
Co-authored papers 2
Release 1.2