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Author Details

Stephen B Howell
Moores Cancer Center and Department of Medicine, University of California
1974
372
79
PMIDPaper TitleJournal TitlePublished Year
36849411Exploiting the Receptor-Binding Domains of R-Spondin 1 to Target Leucine-Rich Repeat-Containin G-Coupled Protein Receptor 5-Expressing Stem Cells in Ovarian Cancer.J Pharmacol Exp Ther2023
36888611Luxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma.PLoS One2023
34843717Luxeptinib disables NLRP3 inflammasome-mediated IL-1β release and pathways required for secretion of inflammatory cytokines IL-6 and TNFα.Biochem Pharmacol2022
35499387Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia.Mol Cancer Ther2022
35715421Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer.NPJ Syst Biol Appl2022
33492953Therapeutic Targeting of Tumor Cells Rich in LGR Stem Cell Receptors.Bioconjug Chem2021
32466781Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer.J Transl Med2020
33109540WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.Anticancer Res2020
31251556Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy.ACS Appl Mater Interfaces2019
31267590Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA.Adv Mater2019
29626126APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.Mol Cancer Ther2018
30555899Tumor Retention of Enzyme-Responsive Pt(II) Drug-Loaded Nanoparticles Imaged by Nanoscale Secondary Ion Mass Spectrometry and Fluorescence Microscopy.ACS Cent Sci2018
29626127APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.Mol Cancer Ther2018
29416699LGR5 and LGR6 in stem cell biology and ovarian cancer.Oncotarget2017
28341300A phase I pharmacokinetic study of intraperitoneal bortezomib and carboplatin in patients with persistent or recurrent ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study.Gynecol Oncol2017
27022832Cellular Delivery of Nanoparticles Revealed with Combined Optical and Isotopic Nanoscopy.ACS Nano2016
27157188Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity.Metallomics2016
26071630A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis.J Control Release2015
26503202Platinum Antitumor Complexes: 50 Years Since Barnett Rosenberg's Discovery.J Clin Oncol2015
26155939Cisplatin inhibits MEK1/2.Oncotarget2015
26205368The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).Metallomics2015
24475288Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells.PLoS One2014
25485574Integrin αV control of Cu homeostasis and cisplatin sensitivity.Cell Cycle2014
25344320Claudin-4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through β-catenin.Cell Commun Signal2014
24967972Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.Biochem Pharmacol2014
25174950Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway.Oncol Rep2014
24522273Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.Metallomics2014
24422495Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water.J Am Chem Soc2014
24475900Tumor infiltrating B-cells are increased in prostate cancer tissue.J Transl Med2014
24447817Characterization of a monoclonal antibody capable of reliably quantifying expression of human Copper Transporter 1 (hCTR1).J Trace Elem Med Biol2014
23053666Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1.Mol Pharmacol2013
23933660In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles.Nat Commun2013
23805314Regulation of the Epithelial-Mesenchymal Transition by Claudin-3 and Claudin-4.PLoS One2013
23803742The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.Metallomics2013
21988542Effects of solution concentration on the physicochemical properties of a polymeric anticancer therapeutic.Mol Pharm2012
23097631Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases.Neoplasia2012
22710939Sec61β controls sensitivity to platinum-containing chemotherapeutic agents through modulation of the copper-transporting ATPase ATP7A.Mol Pharmacol2012
22842628Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling.Biochem Pharmacol2012
22446624A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study.Gynecol Oncol2012
22459168The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin.J Inorg Biochem2012
22569840An all-atom model of the structure of human copper transporter 1.Cell Biochem Biophys2012
20930109Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo.Mol Pharmacol2011
21995420Aggregation properties of a polymeric anticancer therapeutic: a coarse-grained modeling study.J Chem Inf Model2011
21885863A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells.Mol Cancer Ther2011
21630444Cisplatin-loaded porous Si microparticles capped by electroless deposition of platinum.Small2011
21303546Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency.BMC Cancer2011
21360176Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(γ-glutamyl-glutamate) paclitaxel conjugates.J Mol Model2011
21327682Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin.Cancer Chemother Pharmacol2011
21452822Porous silicon nanoparticle photosensitizers for singlet oxygen and their phototoxicity against cancer cells.ACS Nano2011
19685054Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane.Cancer Chemother Pharmacol2010
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Collaborators

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HIV Neurobehavioral Research Center (HNRC), university of california san diego
Co-authored papers 9
University of Southampton Highfield Southampton SO17 1BJ UK.
Co-authored papers 5
The Second Affiliated Hospital of Nanchang University
Co-authored papers 4
Xcenda LLC
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Oncogenesis Thematic Research Center
Co-authored papers 3
Brigham and Women's Hospital
Co-authored papers 3
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University of California San Diego, VA San Diego Healthcare System
Co-authored papers 2
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The University of Queensland Diamantina Institute, The University of Queensland
Co-authored papers 2
David Geffen School of Medicine at university of california los angeles
Co-authored papers 2
Herbert Wertheim School of Public Health, University of California San Diego
Co-authored papers 2
Rutgers Cancer Institute of New Jersey, Rutgers University
Co-authored papers 2
University of Texas Health San Antonio
Co-authored papers 2
Department of Pharmaceutical Sciences, Utrecht University
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
University of California San Diego
Co-authored papers 1
University College London, UK UCL Cancer Institute
Co-authored papers 1
Osaka University
Co-authored papers 1
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Proton Therapy Center- Northwestern University
Co-authored papers 1
Oregon Health & Science University, University of California Berkeley
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Hunter Medical Research Institute
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University of California
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