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Author Details

Sebastian Uhrig
National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ)
2016
39
16
PMIDPaper TitleJournal TitlePublished Year
36789265aRgus: Multilevel visualization of non-synonymous single nucleotide variants & advanced pathogenicity score modeling for genetic vulnerability assessment.Comput Struct Biotechnol J2023
37884744NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology.NPJ Precis Oncol2023
37734378Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity.Cell Rep Med2023
37532709Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification.Nat Commun2023
35045690Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities.Haematologica2022
35668118MCL1 as putative target in pancreatoblastoma.Virchows Arch2022
35366909Correction to: Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations.J Transl Med2022
35871236Genomic architecture of FGFR2 fusions in cholangiocarcinoma and its implication for molecular testing.Br J Cancer2022
35983950Bcl-x<sub>L</sub> as prognostic marker and potential therapeutic target in cholangiocarcinoma.Liver Int2022
35918329Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.Nat Commun2022
36252999IgE type multiple myeloma exhibits hypermutated phenotype and tumor reactive T cells.J Immunother Cancer2022
32949162Integrating proteomics into precision oncology.Int J Cancer2021
34785797Publisher Correction: Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia.Leukemia2021
34808524Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial.ESMO Open2021
34250401Response to Cabozantinib Following Acquired Entrectinib Resistance in a Patient With <i>ETV6-NTRK3</i> Fusion-Positive Carcinoma Harboring the <i>NTRK3</i> <sup>G623R</sup> Solvent-Front Mutation.JCO Precis Oncol2021
34146471A community challenge to evaluate RNA-seq, fusion detection, and isoform quantification methods for cancer discovery.Cell Syst2021
33980253Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations.J Transl Med2021
34112699Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers.Cancer Discov2021
33441414Accurate and efficient detection of gene fusions from RNA sequencing data.Genome Res2021
31558800Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains.Oncogene2020
33442346Prolonged Survival of a Patient with Advanced-Stage Combined Hepatocellular-Cholangiocarcinoma.Case Rep Gastroenterol2020
32913197MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.Nat Commun2020
32843432Successful BRAF/MEK inhibition in a patient with <i>BRAF</i><sup>V600E</sup>-mutated extrapancreatic acinar cell carcinoma.Cold Spring Harb Mol Case Stud2020
32476062An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data.Acta Neuropathol2020
32501622Germline SDHB-inactivating mutation in gastric spindle cell sarcoma.Genes Chromosomes Cancer2020
32385320The landscape of chromothripsis across adult cancer types.Nat Commun2020
32127638Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia.Leukemia2020
30901310<i>RSPO2</i> gene rearrangement: a powerful driver of β-catenin activation in liver tumours.Gut2019
29985981PingPongPro: a tool for the detection of piRNA-mediated transposon-silencing in small RNA-Seq data.Bioinformatics2019
31069492Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.Acta Neuropathol2019
30833416Response to olaparib in a <i>PALB2</i> germline mutated prostate cancer and genetic events associated with resistance.Cold Spring Harb Mol Case Stud2019
31008532Variant classification in precision oncology.Int J Cancer2019
30967556Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.Nat Commun2019
29802158<i>NRG1</i> Fusions in <i>KRAS</i> Wild-Type Pancreatic Cancer.Cancer Discov2018
35135162Validating Comprehensive Next-Generation Sequencing Results for Precision Oncology: The NCT/DKTK Molecularly Aided Stratification for Tumor Eradication Research Experience.JCO Precis Oncol2018
28619747Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer.Cold Spring Harb Mol Case Stud2017
28122742Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.Blood2017
28597939Precision oncology based on omics data: The NCT Heidelberg experience.Int J Cancer2017
27900363Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with <i>PDL1</i> amplification.Cold Spring Harb Mol Case Stud2016
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Collaborators

Stefan Fr??hling
German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT)
Co-authored papers 30
Benedikt Brors
German Cancer Research Center (DKFZ)
Co-authored papers 23
Albrecht Stenzinger
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 23
Peter Horak
German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
Co-authored papers 20
Barbara Hutter
National Center for Tumor Diseases (NCT) Heidelberg
Co-authored papers 20
Simon Kreutzfeldt
German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
Co-authored papers 14
Daniel H??bschmann
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM)
Co-authored papers 12
Christof von Kalle
Berlin Institute of Health at Charite-Universitatsmedizin Berlin
Co-authored papers 10
Peter Schirmacher
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 9
Olaf Neumann
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 7
Volker Endris
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 7
Matthias Schlesner
University of Augsburg
Co-authored papers 6
Jan Budczies
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 5
Stephan Wolf
Co-authored papers 5
Michael Allg??uer
Institute of Pathology, Heidelberg University Hospital
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Martina Kirchner
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 5
Nikolas von Bubnoff
University Hospital of Schleswig-Holstein
Co-authored papers 4
Roland Eils
Berlin Institute of Health (BIH) and Charite
Co-authored papers 4
Frederick Klauschen
Institute of Pathology, Ludwig-Maximilians-Universitat Munchen
Co-authored papers 4
Thomas Longerich
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 4
Anna-Lena Volckmar
Institut fur Pathologie, Universitatsklinikum Heidelberg
Co-authored papers 3
Nagarajan Paramasivam
National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ)
Co-authored papers 3
Gnana Prakash Balasubramanian
Co-authored papers 3
Andreas von Deimling
Co-authored papers 3
Lars Feuerbach
German Cancer Research Center (DKFZ)
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Daniel Kazdal
Institut fur Pathologie, Universitatsklinikum Heidelberg
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Stefan M Pfister
Hopp Children's Cancer Center Heidelberg (KiTZ)
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Marc Zapatka
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Hopp Children's Cancer Center Heidelberg (KiTZ)
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