Author details

Full Name

Dong Wang

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36635281	Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.		2023
35022237	RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.	Proceedings of the National Academy of Sciences of the United States of America	2022
35273076	NDF is a transcription factor that stimulates elongation by RNA polymerase II.	Genes Dev	2022
34853308	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.	Nat Commun	2021
33536256	FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.	Journal of Immunology	2021
33991521	A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models.	Journal of Biological Chemistry	2021
33877330	Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures.	Nucleic Acids Research	2021
34197619	Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs.	Nucleic Acids Research	2021
34140682	Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.	Nat Chem Biol	2021
33239428	The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.	Cancer Res	2021
33271312	Molecular basis of transcriptional pausing, stalling, and transcription-coupled repair initiation.	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms	2021
33303603	Using genetics to reveal protein structure.	Science	2020
32284409	RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-Ï¿ and CH-Ï¿ interactions.	Proceedings of the National Academy of Sciences of the United States of America	2020
31988135	RNA sequencing by direct tagmentation of RNA/DNA hybrids.	Proceedings of the National Academy of Sciences of the United States of America	2020
32989164	Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.	Proc Natl Acad Sci U S A	2020
32817470	A panorama of transcription-coupled repair in yeast chromatin.	Proceedings of the National Academy of Sciences of the United States of America	2020
31200019	3.1 Ã¿ structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids.	J Struct Biol	2019
31179024	Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate.	Nat Energy	2019
30867290	Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog.	Proc Natl Acad Sci U S A	2019
30797902	Structural and biochemical analysis of DNA lesion-induced RNA polymerase II arrest.	Methods	2019
30718278	8-Oxo-guanine DNA damage induces transcription errors by escaping two distinct fidelity control checkpoints of RNA polymerase II.	Journal of Biological Chemistry	2019
29255264	Identification of H3K4me1-associated proteins at mammalian enhancers.	Nat Genet	2018
30174298	Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair.	DNA Repair (Amst)	2018
30127008	Structural basis of RNA polymerase I stalling at UV light-induced DNA damage.	Proceedings of the National Academy of Sciences of the United States of America	2018
29487211	Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II.	Proc Natl Acad Sci U S A	2018
28239446	Mechanism of transcription-coupled DNA modification recognition.	Cell and Bioscience	2017
28933854	Epigenetic DNA Modification N<sup>6</sup>-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing.	J Am Chem Soc	2017
28784758	Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis.	Proc Natl Acad Sci U S A	2017
29168508	Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.	Nature	2017
27791148	RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.	Proc Natl Acad Sci U S A	2016
27304073	Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.	Elife	2016
27105138	RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications.	Transcription	2016
27060150	Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution.	Nucleic Acids Res	2016
27091704	Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue.	Nat Commun	2016
26991064	Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network Models.	Accounts of Chemical Research	2016
26123024	Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.	Nature	2015
25662224	Impact of template backbone heterogeneity on RNA polymerase II transcription.	Nucleic Acids Res	2015
25605892	Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.	Proceedings of the National Academy of Sciences of the United States of America	2015
25762439	An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors.	Genes Dev	2015
26134169	Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes.	PLoS Computational Biology	2015
26392149	RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.	Crit Rev Biochem Mol Biol	2015
24692664	Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.	Nucleic Acids Research	2014
25512493	Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.	Proc Natl Acad Sci U S A	2014
24767259	Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis.	DNA Repair (Amst)	2014
25159856	Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation.	Angewandte Chemie - International Edition	2014
24753580	Millisecond dynamics of RNA polymerase II translocation at atomic resolution.	Proc Natl Acad Sci U S A	2014
24842057	Molecular dynamics simulation study of conformational changes of transcription factor TFIIS during RNA polymerase II transcriptional arrest and reactivation.	PLoS ONE	2014
25074911	Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.	Proceedings of the National Academy of Sciences of the United States of America	2014
24883182	A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression.	Chemical Science	2014
23592966	A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase.	PLoS Computational Biology	2013