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| 37322276 | Adenine transversion editors enable precise, efficient Aâ¿¢T-to-Câ¿¢G base editing in mammalian cells and embryos. | Nat Biotechnol | 2024 |
| 38086269 | WB518, a novel STAT3 inhibitor, effectively alleviates IMQ and TPA-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17. | Int Immunopharmacol | 2024 |
| 36229683 | Engineering a precise adenine base editor with minimal bystander editing. | Nat Chem Biol | 2023 |
| 37634473 | A small molecule BCL6 inhibitor as chemosensitizers in acute myeloid leukemia. | Biomed Pharmacother | 2023 |
| 37753197 | Intelligent tunable CAR-T cell therapy leads the new trend. | Synth Syst Biotechnol | 2023 |
| 37521864 | GPRC5B protects osteoarthritis by regulation of autophagy signaling. | Acta Pharm Sin B | 2023 |
| 38054798 | Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer. | J Med Chem | 2023 |
| 37352607 | A cell-free tissue-engineered tracheal substitute with sequential cytokine release maintained airway opening in a rabbit tracheal full circumferential defect model. | Biomaterials | 2023 |
| 36951370 | Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A<sub>2A</sub> Receptor Antagonists for Cancer Immunotherapy. | J Med Chem | 2023 |
| 37454216 | Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons. | Nat Commun | 2023 |
| 37251628 | Safety and efficacy of CRISPR-based non-viral <i>PD1</i> locus specifically integrated anti-CD19 CAR-T cells in patients with relapsed or refractory Non-Hodgkin's lymphoma: a first-in-human phase I study. | EClinicalMedicine | 2023 |
| 37408308 | LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment. | Mol Ther | 2023 |
| 37334274 | Preclinical characterization of WB737, a potent and selective STAT3 inhibitor, in natural killer/T-cell lymphoma. | MedComm (2020) | 2023 |
| 37130350 | Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance. | J Med Chem | 2023 |
| 36880691 | Discovery of 2<i>H</i>-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy. | J Med Chem | 2023 |
| 36873188 | The role of CYP1A1/2 in cholesterol ester accumulation provides a new perspective for the treatment of hypercholesterolemia. | Acta Pharm Sin B | 2023 |
| 36907956 | SMPD1 expression profile and mutation landscape help decipher genotype-phenotype association and precision diagnosis for acid sphingomyelinase deficiency. | Hereditas | 2023 |
| 36869044 | Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD. | Nat Commun | 2023 |
| 36457249 | Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies. | Mol Ther | 2023 |
| 36795687 | Correction: The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation. | PLoS Pathog | 2023 |
| 36374556 | Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer. | Clin Cancer Res | 2023 |
| 36357717 | Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing. | Nat Biotechnol | 2023 |
| 32815069 | Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor. | Sci China Life Sci | 2022 |
| 35738516 | The combined effects of microplastics and the heavy metal cadmium on the marine periphytic ciliate Euplotes vannus. | Environ Pollut | 2022 |
| 35476936 | Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. | J Med Chem | 2022 |
| 35799694 | Mediastinal Shift Angle in Fetal MRI Is Associated With Prognosis, Severity, and Cardiac Underdevelopment in Left Congenital Diaphragmatic Hernia. | Front Pediatr | 2022 |
| 35640059 | Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. | J Med Chem | 2022 |
| 35721399 | Understanding the pregnant women's experiences during the COVID-19 pandemic in Macao: A qualitative study. | Int J Nurs Sci | 2022 |
| 35691554 | Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration. | J Genet Genomics | 2022 |
| 36437247 | Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. | Cell Death Dis | 2022 |
| 36468018 | Prognostic value of <i>PNN</i> in prostate cancer and its correlation with therapeutic significance. | Front Genet | 2022 |
| 36563137 | Cryo-EM structure of the human adenosine A<sub>2B</sub> receptor-G<sub>s</sub> signaling complex. | Sci Adv | 2022 |
| 36045296 | Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL. | Nature | 2022 |
| 36103247 | Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment. | J Med Chem | 2022 |
| 36266974 | Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. | Adv Sci (Weinh) | 2022 |
| 35922667 | CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β<sup>0</sup>/β<sup>0</sup> transfusion-dependent β-thalassemia. | Nat Med | 2022 |
| 36379203 | Let's turn the CAR-T cells ON and OFF precisely. | Cancer Cell | 2022 |
| 36377663 | BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer. | J Clin Invest | 2022 |
| 35256606 | A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. | Cell Discov | 2022 |
| 35224894 | Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway. | Adv Sci (Weinh) | 2022 |
| 35154008 | G Protein-Coupled Receptors in Osteoarthritis. | Front Endocrinol (Lausanne) | 2022 |
| 35091503 | Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme. | J Neurosci | 2022 |
| 35212542 | Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8<i>H</i>)-one Derivatives as Novel Potent Adenosine A<sub>2A</sub> Receptor Antagonists for Cancer Immunotherapy. | J Med Chem | 2022 |
| 35208999 | A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis. | Molecules | 2022 |
| 35304248 | P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways. | J Invest Dermatol | 2022 |
| 34990752 | An orally available small molecule BCL6 inhibitor effectively suppresses diffuse large B cell lymphoma cells growth in vitro and in vivo. | Cancer Lett | 2022 |
| 35260562 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. | Bone Res | 2022 |
| 34656899 | Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors. | Eur J Med Chem | 2022 |
| 34847079 | RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis. | J Clin Invest | 2022 |
| 34480694 | Inflammatory macrophages exacerbate neutrophil-driven joint damage through ADP/P2Y<sub>1</sub> signaling in rheumatoid arthritis. | Sci China Life Sci | 2022 |