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Author Details

Priyadarshini Jaishankar
Department of Pharmaceutical Chemistry, University of California san francisco
2005
29
15
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37104712Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.J Am Chem Soc2023
37676236Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3Ͽ/ERα Protein-Protein Interaction from Nonselective Fragments.J Am Chem Soc2023
37455289From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.Angew Chem Int Ed Engl2023
35364007Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.Cell Chem Biol2022
32302100Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.ACS Chem Biol2020
30942078Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.ACS Infect Dis2019
31667472Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.Brain Commun2019
31353319Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.Cell Chem Biol2019
31483651Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.J Med Chem2019
29599213Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.Science2018
29844038Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.Antimicrob Agents Chemother2018
30340023Cilia-Associated Oxysterols Activate Smoothened.Mol Cell2018
28759216Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.J Am Chem Soc2017
29045385USP7 small-molecule inhibitors interfere with ubiquitin binding.Nature2017
26789650Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.ChemMedChem2016
27435960Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.Elife2016
25875391Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Elife2015
26057252Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.J Am Chem Soc2015
24259468Tailoring small molecules for an allosteric site on procaspase-6.ChemMedChem2014
25489201Congenital epulis in a newborn: a case report, immunoprofiling and review of literature.Ethiop J Health Sci2014
24977643Broad-spectrum allosteric inhibition of herpesvirus proteases.Biochemistry2014
22296601Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.J Med Chem2012
23227217Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.PLoS One2012
19773167Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.Bioorg Med Chem Lett2009
18055204Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.Bioorg Med Chem Lett2008
17681758A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials.Bioorg Med Chem Lett2007
16387498Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones.Bioorg Med Chem Lett2006
15957907Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate.Org Lett2005
16033280Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones.J Med Chem2005
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Collaborators

Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 28
Brian R Hearn
Department of Pharmaceutical Chemistry and, University of California san francisco
Co-authored papers 8
Peter Walter
University of California san francisco
Co-authored papers 4
Jordan C Tsai
University of California san francisco
Co-authored papers 3
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Jonathan E Gable
Novartis Institute for Tropical Diseases
Co-authored papers 2
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 2
Punitha Vedantham
Department of Pharmaceutical Chemistry and, University of California san francisco
Co-authored papers 2
Markus-Frederik Bohn
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
Carmela Sidrauski
Calico Life Sciences LLC
Co-authored papers 2
Paola Bisignano
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Michael R Hayden
Co-authored papers 1
Jeremy F Reiter
Cardiovascular Research Institute
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Bonne M Thompson
Co-authored papers 1
Alexis Leigh Krup
Gladstone Institutes, University of California san francisco
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
Henry C Nguyen
Shanghai Clinical Research and Trial Center
Co-authored papers 1
Adam Frost
University of California San Francisco
Co-authored papers 1
Erik Verschueren
University of California San Francisco
Co-authored papers 1
Aditya A Anand
University of California san francisco
Co-authored papers 1
Michael C Thompson
University of California
Co-authored papers 1
David R Raleigh
University of California san francisco
Co-authored papers 1
Christopher S Fraser
College of Biological Sciences, University of California davis
Co-authored papers 1
James S Fraser
University of California san francisco
Co-authored papers 1
Jeffrey G McDonald
Co-authored papers 1
Aaron S Mendez
University of California Berkeley
Co-authored papers 1
Dario R Alessi
University of Dundee
Co-authored papers 1
Monika Abedin Sigg
University of California berkeley
Co-authored papers 1
Masaaki Sokabe
College of Biological Sciences, University of California davis
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Release 1.2