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Author Details

Matthew R Redinbo
University of North Carolina at Chapel Hill
1993
158
56
PMIDPaper TitleJournal TitlePublished Year
37918401Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.Cell Chem Biol2024
36914755Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.Nat Microbiol2023
37967733pSK41/pGO1-family conjugative plasmids of Staphylococcus aureus encode a cryptic repressor of replication.Plasmid2023
37633277Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.Cell Chem Biol2023
37122075Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response.Gut Microbes2023
37146137Microbial β-glucuronidases drive human periodontal disease etiology.Sci Adv2023
36623880Relevance of Human Aldoketoreductases and Microbial <i>β</i>-Glucuronidases in Testosterone Disposition.Drug Metab Dispos2023
35013263Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.Nat Commun2022
35841748A structural metagenomics pipeline for examining the gut microbiome.Curr Opin Struct Biol2022
35484230Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.Nat Microbiol2022
36149349The <i>in vitro</i> metabolism and <i>in vivo</i> pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652.Xenobiotica2022
36266335Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome.Nat Microbiol2022
36169030Multi-omic analysis of host-microbial interactions central to the gut-brain axis.Mol Omics2022
35953888Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.Gut Microbes2022
36261446Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice.Sci Rep2022
34140391Plant "helper" immune receptors are Ca<sup>2+</sup>-permeable nonselective cation channels.Science2021
34789871Reporting guidelines for human microbiome research: the STORMS checklist.Nat Med2021
34074730Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation.Drug Metab Dispos2021
32160459Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.J Med Chem2020
31774274Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.ACS Chem Biol2020
32993284Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases.Biochemistry2020
32932981Gut-Derived Protein-Bound Uremic Toxins.Toxins (Basel)2020
32791107The Microbiome Revolution Turns to Cholesterol.Cell Host Microbe2020
32611614The Gut Microbiota Impact Cancer Etiology through "Phase IV Metabolism" of Xenobiotics and Endobiotics.Cancer Prev Res (Phila)2020
32153125Targeting the pregnane X receptor using microbial metabolite mimicry.EMBO Mol Med2020
32170007Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy.Proc Natl Acad Sci U S A2020
30696850Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases.Sci Rep2019
31636122Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens.J Biol Chem2019
31663730Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases.ACS Chem Biol2019
31455640Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure.mSystems2019
31391308Epithelial delamination is protective during pharmaceutical-induced enteropathy.Proc Natl Acad Sci U S A2019
31036600Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages.Infect Immun2019
30729778Selecting a Single Stereocenter: The Molecular Nuances That Differentiate β-Hexuronidases in the Human Gut Microbiome.Biochemistry2019
30553913In Fimo: A Term Proposed for Excrement Examined Experimentally.Gastroenterology2019
30658055Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome.J Mol Biol2019
30376607Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Typeâ¿¿III Pantothenate Kinase (PanK).ChemMedChem2019
29269393Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae.Proc Natl Acad Sci U S A2018
30216370Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus.PLoS One2018
30230652Active site flexibility revealed in crystal structures of Parabacteroides merdae β-glucuronidase from the human gut microbiome.Protein Sci2018
30062115Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception.ACS Cent Sci2018
30301767Three structurally and functionally distinct β-glucuronidases from the human gut microbe <i>Bacteroides uniformis</i>.J Biol Chem2018
29382739Microbial Unmasking of Plant Glycosides.mBio2018
29717993Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1.Acta Crystallogr F Struct Biol Commun2018
29624485Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats.Surg Infect (Larchmt)2018
29295861SPLUNC1 is an allosteric modulator of the epithelial sodium channel.FASEB J2018
29094594Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells.ACS Infect Dis2018
28578872An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.Structure2017
28389557Glucuronides in the gut: Sugar-driven symbioses between microbe and host.J Biol Chem2017
28388695Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21<sup>st</sup> International Symposium on Microsomes and Drug Oxidations (MDO).Acta Pharm Sin B2017
28165446Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.Nat Commun2017
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Collaborators

Christopher L Morton
St. Jude Children's Research Hospital.
Co-authored papers 7
Yves Pommier
Center for Cancer Research, National Cancer Institute
Co-authored papers 4
Peter Kuhn
University of Tubingen
Co-authored papers 3
Matthew C Wolfgang
Co-authored papers 3
Donald P McDonnell
Co-authored papers 3
Bo Li
The University of North Carolina at Chapel Hill
Co-authored papers 3
Ryan Balfour Sartor
University of North Carolina at Chapel Hill
Co-authored papers 3
Scott J Bultman
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Co-authored papers 3
Peter J Turnbaugh
University of California san francisco
Co-authored papers 2
Dennis Goldfarb
Washington University School of Medicine
Co-authored papers 2
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 2
Mehmet Kesimer
Co-authored papers 2
Paromita Mukherjee
University of Cambridge
Co-authored papers 2
William F Marzluff
University of North Carolina at Chapel Hill
Co-authored papers 2
Christian R H Raetz
Co-authored papers 2
Anthony A Fodor
University of North Carolina at Charlotte
Co-authored papers 2
Michael B Major
Washington University in St. Louis
Co-authored papers 2
Andre Franke
Institute of Clinical Molecular Biology, Kiel University
Co-authored papers 1
Ekaterina Smirnova
Institut de Genetique et de Biologie Moleculaire et Cellulaire
Co-authored papers 1
Gianrico Farrugia
Mayo Clinic Gastroenterology and Hepatology, Mayo Clinic
Co-authored papers 1
Jeffrey Roach
Co-authored papers 1
Eran Segal
Weizmann Institute of Science
Co-authored papers 1
Jennifer M Fettweis
Virginia Commonwealth University
Co-authored papers 1
Weida Tong
National Center for Toxicological Research
Co-authored papers 1
Mathew W Wright
Stanford University School of Medicine
Co-authored papers 1
Ryan T Demmer
University of Minnesota, Mailman School of Public Health Columbia University
Co-authored papers 1
Wendell D Jones
Department of Bioinformatics and Clinical Systems
Co-authored papers 1
Pieter C Dorrestein
Co-authored papers 1
Francine Z Marques
Monash University
Co-authored papers 1
Suzanne Devkota
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 1
Release 1.2