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Author Details

Richard Koche
Memorial Sloan Kettering Cancer Center
2005
97
44
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37934007Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function.Cancer Discov2024
37934007Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function.Cancer Discov2024
37992313Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable.Clin Cancer Res2024
37992313Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable.Clin Cancer Res2024
36755094TET2 guards against unchecked BATF3-induced CAR T cell expansion.Nature2023
37822508KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis.iScience2023
37987160An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions.EMBO J2023
37553760GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.Cancer Discov2023
38056453A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas.Dev Cell2023
37868040Mutational topography reflects clinical neuroblastoma heterogeneity.Cell Genom2023
37609261Interferon response and epigenetic modulation by <i>SMARCA4</i> mutations drive ovarian tumor immunogenicity.bioRxiv2023
37402365Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.Mol Cell2023
37142849Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.Nat Genet2023
37261974MLL3 regulates the <i>CDKN2A</i> tumor suppressor locus in liver cancer.Elife2023
36755094TET2 guards against unchecked BATF3-induced CAR T cell expansion.Nature2023
37311462Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination.Mol Cell2023
37167403Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.Science2023
37531417Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.Sci Transl Med2023
37553760GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.Cancer Discov2023
38056453A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas.Dev Cell2023
37987160An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions.EMBO J2023
37609261Interferon response and epigenetic modulation by <i>SMARCA4</i> mutations drive ovarian tumor immunogenicity.bioRxiv2023
37822508KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis.iScience2023
37868040Mutational topography reflects clinical neuroblastoma heterogeneity.Cell Genom2023
37531417Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.Sci Transl Med2023
37311462Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination.Mol Cell2023
37142849Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.Nat Genet2023
37402365Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.Mol Cell2023
37167403Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.Science2023
37261974MLL3 regulates the <i>CDKN2A</i> tumor suppressor locus in liver cancer.Elife2023
34802033Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer.Oncogene2022
35952322Prospective Clinical Genomic Profiling of Ewing Sarcoma: <i>ERF</i> and <i>FGFR1</i> Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance.JCO Precis Oncol2022
35421216BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.Blood2022
35789380PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.Cancer Discov2022
35787684CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.Nat Cell Biol2022
35355015Anatomic position determines oncogenic specificity in melanoma.Nature2022
35852856Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.J Clin Invest2022
34802033Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer.Oncogene2022
35042235Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs.Blood Adv2022
34815254Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy.Cancer Res2022
34935874TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.J Exp Med2022
35286385HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.Blood2022
35789380PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.Cancer Discov2022
35787684CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.Nat Cell Biol2022
35852856Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.J Clin Invest2022
35421216BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.Blood2022
35355015Anatomic position determines oncogenic specificity in melanoma.Nature2022
35952322Prospective Clinical Genomic Profiling of Ewing Sarcoma: <i>ERF</i> and <i>FGFR1</i> Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance.JCO Precis Oncol2022
35286385HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.Blood2022
35042235Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs.Blood Adv2022
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Collaborators

Scott A Armstrong
Boston Children's Hospital
Co-authored papers 26
Elisa de Stanchina
Co-authored papers 14
Anton G Henssen
Co-authored papers 10
Alex Kentsis
Memorial Sloan-Kettering Cancer Center
Co-authored papers 9
Bradley E Bernstein
Broad Institute of MIT and Harvard
Co-authored papers 9
Elias Rodriguez-Fos
Co-authored papers 8
Montserrat Puiggròs
Co-authored papers 7
David Torrents
Institucio Catalana de Recerca i Estudis Avancats (ICREA)
Co-authored papers 7
Mithat Gonen
Co-authored papers 7
Kristian Helin
The Institute of Cancer Research
Co-authored papers 7
Cristina R Antonescu
Memorial Sloan Kettering Cancer Center
Co-authored papers 6
Angelika Eggert
Co-authored papers 6
Ari Melnick
Co-authored papers 6
Nicholas D Socci
Co-authored papers 6
James E Bradner
Co-authored papers 6
Johannes H Schulte
Co-authored papers 6
Amit U Sinha
Memorial Sloan Kettering Cancer Center
Co-authored papers 6
Martin S Tallman
Memorial Sloan-Kettering Cancer Center
Co-authored papers 5
Christopher E Mason
Feil Family Brain and Mind Research Institute.
Co-authored papers 5
Dana Pe'er
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 5
Ian C MacArthur
Co-authored papers 5
Eric Still
Co-authored papers 5
Zhiping Weng
University of Massachusetts Medical School
Co-authored papers 4
Aniruddha J Deshpande
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
Jiali Zhuang
Co-authored papers 4
Charles M Rudin
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Yu Chen
School of Pharmacy, University of Wisconsin-Madison
Co-authored papers 4
Christina S Leslie
Co-authored papers 4
Mazhar Adli
Co-authored papers 4
Charles L Sawyers
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Release 1.2