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Author Details

Jang-Ho J Cha
Novartis Institutes for Biomedical Research
1986
79
39
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35241644An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.Nat Commun2022
35947423Description of the Method for Evaluating Digital Endpoints in Alzheimer Disease Study: Protocol for an Exploratory, Cross-sectional Study.JMIR Res Protoc2022
34025472A Study of Novel Exploratory Tools, Digital Technologies, and Central Nervous System Biomarkers to Characterize Unipolar Depression.Front Psychiatry2021
28044255Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study.Adv Ther2017
27253658Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study.J Clin Psychopharmacol2016
25349168ADAR2-dependent GluA2 editing regulates cocaine seeking.Mol Psychiatry2015
26240742A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone.Ther Adv Drug Saf2015
24105466MeCP2: a novel Huntingtin interactor.Hum Mol Genet2014
23288715Feasibility and impact on surgical outcomes of modified double-stapling technique for patients undergoing laparoscopic anterior resection.J Gastrointest Surg2013
25062675Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease.J Huntingtons Dis2013
22043863Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters.J Neurochem2012
22848491Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.PLoS One2012
21496570Molecular biology of Huntington's disease.Handb Clin Neurol2011
19850138Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection".Neuroimage2010
20810894Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine.J Neurosci2010
20613636Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.J Neuropathol Exp Neurol2010
18818671Mechanisms of distribution of mouse beta-galactosidase in the adult GM1-gangliosidosis brain.Gene Ther2009
18400894Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation.J Neurosci2008
18923047Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.J Neurosci2008
18931668Linking SNPs to CAG repeat length in Huntington's disease patients.Nat Methods2008
18945913Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking.J Neurosci2008
1860809150bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis.Amyotroph Lateral Scler2008
18278040CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.Nat Neurosci2008
17519223Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Hum Mol Genet2007
17544587Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.Neuroscience2007
17550429Dopamine release is impaired in a mouse model of DYT1 dystonia.J Neurochem2007
17376435Finding diamonds in the rubble.Exp Neurol2007
17409194Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.Hum Mol Genet2007
17467140Transcriptional signatures in Huntington's disease.Prog Neurobiol2007
16595660Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.J Biol Chem2006
17017871Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death).Curr Alzheimer Res2006
17192438Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.J Neurosci2006
17182994Case records of the Massachusetts General Hospital. Case 39-2006. A 24-year-old woman with systemic lupus erythematosus, seizures, and right arm weakness.N Engl J Med2006
16820007Huntingtin inclusions do not down-regulate specific genes in the R6/2 Huntington's disease mouse.Eur J Neurosci2006
16932577Mechanisms of disease: Histone modifications in Huntington's disease.Nat Clin Pract Neurol2006
16914060Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.BMC Med Genet2006
16442295Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.Neurobiol Dis2006
16183657Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.Hum Mol Genet2005
14993615Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.Proc Natl Acad Sci U S A2004
15717013The paradigm of Huntington's disease: therapeutic opportunities in neurodegeneration.NeuroRx2004
15201461Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain.Methods Mol Biol2004
15201460Neurotransmitter receptor analysis in transgenic mouse models.Methods Mol Biol2004
12498958Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.Neurobiol Aging2003
12900792A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study.Am J Hum Genet2003
14678777Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation.Neurobiol Dis2003
14597227Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology.Brain Res Mol Brain Res2003
12593136Diffusion-weighted magnetic resonance imaging abnormalities in Bartonella encephalopathy.J Neuroimaging2003
12799135Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation.Mol Cell Neurosci2003
12165556Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.Hum Mol Genet2002
12354289Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease.J Neurochem2002
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Collaborators

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Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd.
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Co-authored papers 8
CHDI Management/CHDI Foundation
Co-authored papers 8
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Co-authored papers 7
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 6
Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 5
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MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 5
Co-authored papers 5
Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 5
University of Alabama at Birmingham
Co-authored papers 4
Co-authored papers 4
Center for Regenerative Therapies Dresden, Technische Universitat Dresden
Co-authored papers 4
Institute of Biotechnology, University of Lausanne
Co-authored papers 4
University of Virginia
Co-authored papers 4
University of California san francisco
Co-authored papers 4
Co-authored papers 4
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 3
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Neurodegenerative Diseases Research Unit
Co-authored papers 3
Department of Food Engineering, Harbin University
Co-authored papers 3
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Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Belfast City Hospital
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