Author details

Full Name

Natasha J Caplen

Affiliation

ORCID

Career Start Year

1990

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37042074	The HNRNPF/H RNA binding proteins and disease.		2023
37645932	EWSR1's visual modalities are defined by its association with nucleic acids and RNA polymerase II.	bioRxiv	2023
37129573	The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.	J Cell Sci	2023
35047826	Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.	NAR Cancer	2022
35639772	HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript.	Nucleic Acids Research	2022
31407506	Fusion transcripts: Unexploited vulnerabilities in cancer?	Wiley interdisciplinary reviews. RNA	2020
32127464	CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.	Mol Cancer Ther	2020
33043516	Cancer biology functional genomics: From small RNAs to big dreams.	Molecular Carcinogenesis	2020
30709910	MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.	Proc Natl Acad Sci U S A	2019
31511320	HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction.	RNA	2019
29873416	EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.	Mol Carcinog	2018
28881656	BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).	Oncotarget	2017
27558154	Identification of therapeutic targets applicable to clinical strategies in ovarian cancer.	BMC Cancer	2016
26776507	Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.	Cell Rep	2016
25722303	Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins.	Mol Cancer Res	2015
25193464	Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity.	Cancer Lett	2014
25245095	Selective targeting of KRAS-mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-mutant cells.	Oncotarget	2014
24745479	Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.	Breast Cancer Res	2014
25086928	Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.	Clin Exp Metastasis	2014
23319804	Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/Î²-catenin pathway in colorectal cancer.	Cancer Res	2013
23790466	Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation.	Eur J Cancer	2013
22110125	p53-Dependent induction of PVT1 and miR-1204.	Journal of Biological Chemistry	2012
22812567	Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.	Breast Cancer Res	2012
22558003	The 8q24 gene desert: an oasis of non-coding transcriptional activity.	Frontiers in Genetics	2012
22216762	Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.	Mol Cancer	2012
21814748	Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA.	Breast Cancer Research and Treatment	2011
21495870	Genomic instability and mouse microRNAs.	Toxicology Mechanisms and Methods	2011
20473941	A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.	Int J Cancer	2011
21834757	RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.	Curr Cancer Drug Targets	2011
19821025	Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome.	Breast Cancer Res Treat	2010
19416980	Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.	J Biol Chem	2009
19741151	Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].	J Pharmacol Exp Ther	2009
18314482	The identification of microRNAs in a genomically unstable region of human chromosome 8q24.	Mol Cancer Res	2008
18382425	Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.	Br J Cancer	2008
18194563	Pvt1-encoded microRNAs in oncogenesis.	Retrovirology	2008
18653764	Allele-specific silencing of the dominant disease allele in sialuria by RNA interference.	FASEB J	2008
18638396	SpliceCenter: a suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies.	BMC Bioinformatics	2008
17113784	MicroRNAs and genomic instability.	Semin Cancer Biol	2007
17392344	Multiplexing siRNAs to compress RNAi-based screen size in human cells.	Nucleic Acids Res	2007
17477824	Applications of RNA interference in mammalian systems.	Annual Review of Genomics and Human Genetics	2007
17088436	Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.	Mol Cancer Ther	2006
16764866	Mismatched siRNAs downregulate mRNAs as a function of target site location.	FEBS Letters	2006
16651436	Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.	Cancer Res	2006
16480492	Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.	Respiratory Research	2006
16530703	Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.	Cancer Cell	2006
15629712	Defining and assaying RNAi in mammalian cells.	Molecular Cell	2005
16149909	Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions.	Hum Gene Ther	2005
15661896	Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.	Journal of Immunology	2005
15026990	In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.	Journal of Gene Medicine	2004
15286770	RNAi quashes polyQ.	Nature Medicine	2004