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Author Details

Jiefei Tong
Hospital for Sick Children
1993
54
31
PMIDPaper TitleJournal TitlePublished Year
36214668Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non-Small Cell Lung Cancer.Mol Cancer Res2023
35595168Proteomic Characterization of a Candidate Polygenic Driver of Metabolism in Non-small Cell Lung Cancer.J Mol Biol2022
35383171Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes.Nat Commun2022
35613471Engineered SH2 Domains for Targeted Phosphoproteomics.ACS Chem Biol2022
35362478Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.J Clin Invest2022
32842143Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.Blood2021
32903271Cancer proteome and metabolite changes linked to SHMT2.PLoS One2020
31822558The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.J Biol Chem2020
30431205Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis.Protein Sci2019
31330989Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer.Cancers (Basel)2019
31292163ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma.Cancer Res2019
30713027Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.Structure2019
30938160Evosep One Enables Robust Deep Proteome Coverage Using Tandem Mass Tags while Significantly Reducing Instrument Time.J Proteome Res2019
30158528A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.Nat Commun2018
27750381Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.Int J Cancer2017
28285997CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity.Curr Biol2017
28176486Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia.Proteomics2017
28673317The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis.J Hematol Oncol2017
28894103The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.Nat Commun2017
28933784Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis.Cell Death Dis2017
27880036Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS.Proteomics2017
26825710The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.Blood2016
27797343Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.J Clin Invest2016
27152361Identification of human plasma cells with a lamprey monoclonal antibody.JCI Insight2016
25587033Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.Mol Cell Proteomics2015
25784717CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration.Mol Cancer Res2015
24430869The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.Mol Biol Cell2014
25448412Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues.Int J Biochem Cell Biol2014
25429762Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact.Nat Commun2014
25292214Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.Sci Signal2014
24797263Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.Mol Cell Proteomics2014
23287719A strategy for modulation of enzymes in the ubiquitin system.Science2013
23825523Odin (ANKS1A) modulates EGF receptor recycling and stability.PLoS One2013
22554165Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue.Clin Proteomics2012
20815376Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures.J Proteome Res2011
21609022Quantitative phospho-proteomic profiling of hepatocyte growth factor (HGF)-MET signaling in colorectal cancer.J Proteome Res2011
21135258A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.Blood2011
20205385Measurement of protein phosphorylation stoichiometry by selected reaction monitoring mass spectrometry.J Proteome Res2010
19531499Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.Mol Cell Proteomics2009
19901323Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition.Proc Natl Acad Sci U S A2009
18271526Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.J Proteome Res2008
16889898Emerging applications for phospho-proteomics in cancer molecular therapeutics.Biochim Biophys Acta2006
12486127Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity.J Biol Chem2003
12435363UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.Dev Biol2002
11533026Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.J Biol Chem2001
11572780Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.Cell2001
10493909HEK-293 cells possess a carbachol- and thapsigargin-sensitive intracellular Ca2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine.Biochem J1999
9873004Measurement of resting cytosolic Ca2+ concentrations and Ca2+ store size in HEK-293 cells transfected with malignant hyperthermia or central core disease mutant Ca2+ release channels.J Biol Chem1999
10097181A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease.Proc Natl Acad Sci U S A1999
9334205Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease.J Biol Chem1997
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Collaborators

Michael F Moran
Hospital for Sick Children, University of Toronto
Co-authored papers 42
Paul Taylor
Hospital for Sick Children
Co-authored papers 22
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 13
Nhu-An Pham
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Geoffrey Liu
The Princess Margaret Cancer Centre/University of Toronto
Co-authored papers 7
Frances A Shepherd
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 6
Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 5
Ming Li
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Suzanne Trudel
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 5
Tony Pawson
Co-authored papers 4
Yuhong Wei
Rosalind and Morris Goodman Cancer Institute, McGill University
Co-authored papers 4
Vladimir Ignatchenko
Margaret Cancer Center
Co-authored papers 4
David H MacLennan
Co-authored papers 4
Melania Pintilie
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Shingo Sakashita
National Cancer Center Exploratory Oncology Research & Clinical Trial Center
Co-authored papers 3
Naoki Yanagawa
Yamagata Prefectural Central Hospital
Co-authored papers 3
Dennis Wang
Sheffield Institute of Translational Neuroscience, University of Sheffield
Co-authored papers 3
Chang-Qi Zhu
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Vibha Raghavan
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 3
Lei Li
Hospital for Sick Children
Co-authored papers 3
Jason Moffat
University of Toronto
Co-authored papers 2
Dan Strumpf
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
Thomas K Waddell
Toronto General Hospital
Co-authored papers 2
Roya Navab
Princess Margaret Cancer Centre, University Health Network
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Shawn S-C Li
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Cynthia Hawkins
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Release 1.2