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Author Details

Michael J Chalmers
Lilly Research Laboratories
1999
70
37
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
31045344Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb.Anal Chem2019
31724102A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.J Am Soc Mass Spectrom2019
29329326Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.PLoS One2018
29937982Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor.ACS Med Chem Lett2018
30258540Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands.ACS Med Chem Lett2018
27807976A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.J Phys Chem B2017
29030554HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.Nat Commun2017
27700100Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis.J Proteome Res2017
26795112Structural features underlying raloxifene's biophysical interaction with bone matrix.Bioorg Med Chem2016
27224086Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.Anal Chem2016
27544045Corrigendum to "Structural features underlying raloxifene's biophysical interaction with bone matrix" [Bioorg. Med. Chem. 24 (2016) 759-767].Bioorg Med Chem2016
26854023A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.J Med Chem2016
26289479Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.Nat Commun2015
24187139Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain.J Biol Chem2014
25352669New approach to capture and characterize synaptic proteome.Proc Natl Acad Sci U S A2014
24974344HDX reveals unique fragment ligands for the vitamin D receptor.Bioorg Med Chem Lett2014
24560804Nitric oxide-induced conformational changes in soluble guanylate cyclase.Structure2014
23290725Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities.Structure2013
24076403Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.Structure2013
23884631Time window expansion for HDX analysis of an intrinsically disordered protein.J Am Soc Mass Spectrom2013
23636859Decoding split and pool combinatorial libraries with electron-transfer dissociation tandem mass spectrometry.J Am Soc Mass Spectrom2013
22131230Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution.J Am Soc Mass Spectrom2012
22692830HDX workbench: software for the analysis of H/D exchange MS data.J Am Soc Mass Spectrom2012
22456874Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates.Mol Biosyst2012
22582136Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs.ACS Med Chem Lett2012
22244763Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.Structure2012
22039047Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors.J Biol Chem2012
22116026Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.Science2012
21478866DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.Nat Struct Mol Biol2011
22270625A biomimetic polyketide-inspired approach to small-molecule ligand discovery.Nat Chem2011
22049338Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.Proc Natl Acad Sci U S A2011
22160701Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.Proc Natl Acad Sci U S A2011
21892191Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.Nature2011
21889352Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.Structure2011
21528013Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data.Int J Mass Spectrom2011
21329427Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions.Expert Rev Proteomics2011
21415010The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.Nucleic Acids Res2011
20058880Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange.Anal Chem2010
20947021Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.Structure2010
20651683Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.Nature2010
20335173A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.J Biol Chem2010
19965867Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.J Biol Chem2010
19135386HD desktop: an integrated platform for the analysis and visualization of H/D exchange data.J Am Soc Mass Spectrom2009
19583303Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.Biochemistry2009
19731897Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles.J Org Chem2009
19739677Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.Biochemistry2009
19574232Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.J Biol Chem2009
18474858Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.Proc Natl Acad Sci U S A2008
17506883The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data.BMC Bioinformatics2007
17937915Partial agonists activate PPARgamma using a helix 12 independent mechanism.Structure2007
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Collaborators

Patrick R Griffin
The Scripps Research Institute
Co-authored papers 41
Bruce D Pascal
The Scripps Research Institute
Co-authored papers 21
Jeffrey A Dodge
Lilly Research Laboratories
Co-authored papers 16
Alfonso Espada
Co-authored papers 7
Howard Broughton
Lilly Research Laboratories
Co-authored papers 6
Theodore M Kamenecka
Co-authored papers 6
Christopher L Hendrickson
Florida State University
Co-authored papers 5
David Marciano
Stanford Cardiovascular Institute (L.W., Stanford University School of Medicine
Co-authored papers 3
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 2
Christopher C Mader
Co-authored papers 1
Jiri Mestecky
Co-authored papers 1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Christine Humblet
Lilly Research Laboratories
Co-authored papers 1
Hualiang Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Co-authored papers 1
Malvina Papanastasiou
Co-authored papers 1
C David Allis
The Rockefeller University
Co-authored papers 1
Antony Rosen
Johns Hopkins University
Co-authored papers 1
Yuqing E Chen
Co-authored papers 1
Stephan C Sch??rer
Institute for Data Science and Computing, University of Miami
Co-authored papers 1
Karen L Abbott
Co-authored papers 1
Riccardo Pellarin
CNRS UMR 5086 and Universite Claude Bernard Lyon 1
Co-authored papers 1
Frances Tung
Co-authored papers 1
Matthias Blüher
Co-authored papers 1
Xin-An Liu
Co-authored papers 1
John D Lambris
Co-authored papers 1
Xin Zhang
Co-authored papers 1
Dušica VidoviĿ
Co-authored papers 1
Robert J Chalkley
Department of Pharmaceutical Chemistry, University of California at San Francisco
Co-authored papers 1
Timothy A Cross
Florida State University
Co-authored papers 1
John F Hunt
Columbia University
Co-authored papers 1
Release 1.2