Author details

Full Name

Walter J Koch

Affiliation

ORCID

Career Start Year

1987

Papers

516

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34997361	Pepducin ICL1-9-Mediated Î²2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a G Protein/ROCK/PKD-Sensitive Manner.	Cardiovascular Drugs and Therapy	2023
37707557	GSK-3Î± aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion.	J Mol Med (Berl)	2023
36884028	Î²3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.		2023
36883479	Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals.		2023
37013982	Novel roles for G protein-coupled receptor kinases in cardiac injury and repair.		2023
37437402	Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.		2023
34812500	Cardiomyocyte-GSK-3Î² deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms.	J Cell Physiol	2022
36240436	Ectonucleoside triphosphate diphosphohydrolase-1 (CD39) impacts TGF-Î²1 responses: insights into cardiac fibrosis and function following myocardial infarction.	American Journal of Physiology - Heart and Circulatory Physiology	2022
35758037	Not All Î²-Receptors Appear the Same in Heart Failure: Emergence of Î²3-Agonists as a Therapeutic Option.	Circulation: Heart Failure	2022
35878706	GRK2 in cardiovascular disease and its potential as a therapeutic target.	Journal of Molecular and Cellular Cardiology	2022
35418836	Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders.	Frontiers in Cellular Neuroscience	2022
36269835	CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection.	Science advances	2022
35793439	GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12.	Blood advances	2022
35673580	Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition.	Theranostics	2022
35611695	Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.	Circulation Research	2022
35358843	Enhanced NCLX-dependent mitochondrial Ca efflux attenuates pathological remodeling in heart failure.	Journal of Molecular and Cellular Cardiology	2022
35540100	Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels.	JACC: Basic to Translational Science	2022
36445563	Beta-3 adrenergic receptor overexpression reverses aortic stenosis-induced heart failure and restores balanced mitochondrial dynamics.	Basic Research in Cardiology	2022
33892492	Epidermal growth factor receptor-dependent maintenance of cardiac contractility.	Cardiovascular Research	2022
33560342	G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.	Cardiovasc Res	2022
34763521	Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function.	Circulation Research	2022
34628272	LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury.	Redox Biology	2021
33539225	KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy.	Circulation Research	2021
34063503	In Vivo Stimulation of Î±- and Î²-Adrenoceptors in Mice Differentially Alters Small RNA Content of Circulating Extracellular Vesicles.	Cells	2021
33785612	A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.	Science Signaling	2021
33671974	Targeting GRK5 for Treating Chronic Degenerative Diseases.	International Journal of Molecular Sciences	2021
33513081	Characterization of Î²ARKct engineered cellular extracellular vesicles and model specific cardioprotection.	American Journal of Physiology - Heart and Circulatory Physiology	2021
33714738	Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production.	Redox Biol	2021
33713399	Metabolomics, heart disease and aging.	Aging	2021
33500351	GRK5 is a regulator of fibroblast activation and cardiac fibrosis.	Proceedings of the National Academy of Sciences of the United States of America	2021
33377274	Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging.	Aging Cell	2021
33026132	Unlocking Nature's Biosynthetic Power-Metabolic Engineering for the Fermentative Production of Chemicals.	Angewandte Chemie - International Edition	2021
33284975	Adding another GRK to the fire of heart failure.	European Heart Journal	2021
33411629	Thomas L. Force, MD: 1951-2020: A Brilliant Physician-Scientist Gone Too Soon.	Circ Res	2021
33430208	Nitric Oxide and S-Nitrosylation in Cardiac Regulation: G Protein-Coupled Receptor Kinase-2 and Î²-Arrestins as Targets.	International Journal of Molecular Sciences	2021
33157191	Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart.	Journal of Controlled Release	2020
32324169	B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension.	JCI insight	2020
32358483	Author Correction: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis.	Nat Commun	2020
32216616	Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.	American Journal of Physiology - Heart and Circulatory Physiology	2020
31815595	Interleukin-10 Deficiency Alters Endothelial Progenitor Cell-Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment.	Circulation Research	2020
32096362	Metabolic Crosstalk between the Heart and Fat.	Korean Circulation Journal	2020
31918577	Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice.	Circulation	2020
32640834	Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy.	Circulation	2020
32942572	Identification and Comparison of Hyperglycemia-Induced Extracellular Vesicle Transcriptome in Different Mouse Stem Cells.	Cells	2020
30782477	Various effects of AAV9-mediated Î²ARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and Î´-sarcoglycan-deficient (Sgcd-/-) mice.	Neuromuscular Disorders	2019
30605412	Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.	Circ Res	2019
29917053	Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging.	J Gerontol A Biol Sci Med Sci	2019
30639431	Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.	International Journal of Biochemistry and Cell Biology	2019
30611795	Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.	Journal of Molecular and Cellular Cardiology	2019
31188593	Correction to "Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine".	Journal of Medicinal Chemistry	2019