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Author Details

Sanjay K Nigam
university of california san diego
1986
194
72
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36692015The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism.JCI Insight2023
36979028Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice.Antioxidants (Basel)2023
36316339Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions.Sci Rep2022
35490380Blockade of Organic Anion Transport in Humans After Treatment With the Drug Probenecid Leads to Major Metabolic Alterations in Plasma and Urine.Clin Pharmacol Ther2022
36230695Organic Anion Transporters (OAT) and Other SLC22 Transporters in Progression of Renal Cell Carcinoma.Cancers (Basel)2022
33937275Uremic Toxins in Organ Crosstalk.Front Med (Lausanne)2021
33785360A key role for the transporter OAT1 in systemic lipid metabolism.J Biol Chem2021
33757768Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.J Biol Chem2021
34684013Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease.Pharmaceutics2021
32271169Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.JCI Insight2020
30422383Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development.Am J Med Genet A2019
31417100A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis.Sci Rep2019
30728454Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.Nat Rev Nephrol2019
29309257The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.Annu Rev Pharmacol Toxicol2018
29847376The systems biology of uric acid transporters: the role of remote sensing and signaling.Curr Opin Nephrol Hypertens2018
29412698Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.Am J Physiol Renal Physiol2018
29746174Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication.Expert Opin Drug Metab Toxicol2018
28765282The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.J Biol Chem2017
28694431Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes.Sci Rep2017
27044799Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.Drug Metab Dispos2016
27440044An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.J Biol Chem2016
27488918Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.J Pharmacol Exp Ther2016
27274832Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.Clin Kidney J2016
27046168Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2.PLoS One2016
25540139The organic anion transporter (OAT) family: a systems biology perspective.Physiol Rev2015
26490509Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters.Clin J Am Soc Nephrol2015
26251846Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways.Biochem Biophys Rep2015
26358290Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors.Drug Metab Dispos2015
26536134Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.PLoS One2015
26554899Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.Elife2015
26088472Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.Clin Pharmacol Ther2015
25630970The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells.FASEB J2015
25475361What do drug transporters really do?Nat Rev Drug Discov2015
24488503Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.Pediatr Nephrol2014
24854650Cellular and developmental strategies aimed at kidney tissue engineering.Nephron Exp Nephrol2014
24503495Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease.Curr Opin Organ Transplant2014
23196129Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue.Neurosci Lett2013
24038112Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters.Mol Pharmacol2013
24191267Concise review: can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs?Stem Cells Transl Med2013
24143282GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling.Biol Open2013
23920220Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.Drug Metab Dispos2013
23949796Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease.J Am Soc Nephrol2013
23778708How much do we know about drug handling by SLC and ABC drug transporters in children?Clin Pharmacol Ther2013
22338083A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.Am J Physiol Renal Physiol2012
23060443N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.J Biol Chem2012
22808265Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule.PLoS One2012
22843032The storytelling brain. Commentary on "On social attribution: implications of recent cognitive neuroscience research for race, law, and politics".Sci Eng Ethics2012
22639247In vitro culture of embryonic kidney rudiments and isolated ureteric buds.Methods Mol Biol2012
22290330A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development.Dev Biol2012
20921221Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling.J Biol Chem2011
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Collaborators

University of California
Co-authored papers 26
Yale University School of Medicine
Co-authored papers 6
University of California
Co-authored papers 4
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 4
University of California San Diego
Co-authored papers 4
University of California San Diego
Co-authored papers 3
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
National Institutes of Health/National Institute of Environmental Health Sciences
Co-authored papers 2
Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Co-authored papers 2
Cancer Research Institute, Kanazawa University
Co-authored papers 2
Co-authored papers 2
University of California San Diego
Co-authored papers 2
Lady Hardinge Medical College and Associated SSK and KSC Hospitals
Co-authored papers 2
Skaggs School of Pharmacy and Pharmaceutical Sciences.
Co-authored papers 2
Co-authored papers 2
University of California
Co-authored papers 1
University of California at San Diego
Co-authored papers 1
Co-authored papers 1
University of Michigan-Ann Arbor
Co-authored papers 1
Clinical Metabolomics
Co-authored papers 1
Co-authored papers 1
university of california san diego School of Medicine
Co-authored papers 1
Center for Computational Biology & Bioinformatics (CCBB), University of California
Co-authored papers 1
National Institutes of Health, National Institute of Diabetes
Co-authored papers 1
National Institute On Aging
Co-authored papers 1
Department of Pediatrics/Rady Children's Hospital, University of California San Diego
Co-authored papers 1
Vanderbilt University Medical Center
Co-authored papers 1
University of California, San Diego School of Medicine
Co-authored papers 1