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Author Details

Joan Heller Brown
1972
229
88
PMIDPaper TitleJournal TitlePublished Year
36899057A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling.2023
37662205Nitric Oxide modulates spontaneous Ca release and ventricular arrhythmias during β-adrenergic signalling through -nitrosylation of Calcium/Calmodulin dependent kinase II.2023
37961889Nitric Oxide Modulates Ca Leak and Arrhythmias via S-Nitrosylation of CaMKII.2023
34706158Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.Mol Oncol2022
35760846RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria.Cell Death and Differentiation2022
35411847Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice.eLife2022
35298299Splicing and Dicing: A Deeper Dive Into CaMKIIδ and Cardiac Inflammation.Circulation Research2022
35005327The contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies.Current Opinion in Physiology2021
33525909SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification.Journal of the American Heart Association2021
33922643ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.International Journal of Molecular Sciences2021
32970800Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration.Journal of Experimental Medicine2021
32821022CaMKIIδC Drives Early Adaptive Ca<sup>2+</sup> Change and Late Eccentric Cardiac Hypertrophy.Circ Res2020
32134364Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes.Circulation Research2020
32881857Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling.PLoS Biol2020
31441689Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling.American Journal of Physiology - Heart and Circulatory Physiology2019
30635403Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload.Journal of Biological Chemistry2019
29384700Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice.American Journal of Physiology - Regulatory Integrative and Comparative Physiology2018
29887596YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.Oncogene2018
29925681CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis.JCI insight2018
29953931RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes.Cellular Signalling2018
30571348Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling.Circulation2018
30520731A secretory pathway kinase regulates sarcoplasmic reticulum Ca<sup>2+</sup> homeostasis and protects against heart failure.Elife2018
28017639Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection.Journal of Molecular and Cellular Cardiology2017
28487342Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.Circulation: Heart Failure2017
28577576Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.Journal of Neuroinflammation2017
28882890C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.J Biol Chem2017
28737214Decline in cellular function of aged mouse c-kit cardiac progenitor cells.Journal of Physiology2017
28077321CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.Journal of Molecular and Cellular Cardiology2017
26494861Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.Mol Pharmacol2016
27231311Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis.Journal of Applied Physiology2016
26742842Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB.Journal of Biological Chemistry2016
27094722Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs.Cellular Signalling2016
26915632Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload.Circulation2016
26459764Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation.Molecular and Cellular Biology2016
26080362CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.Journal of Molecular and Cellular Cardiology2015
25453218PLCε mediated sustained signaling pathways.Advances in Biological Regulation2015
25904553G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.Molecular Pharmacology2015
25605649Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.Circulation Research2015
25943115The First 50 Years of Molecular Pharmacology.Molecular Pharmacology2015
26350460Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ.Journal of Biological Chemistry2015
25106095Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.Journal of Molecular and Cellular Cardiology2014
25452163CaMKII confirms its promise in ischaemic heart disease.European Journal of Heart Failure2014
24444709A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics.Cellular Signalling2014
24277866Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes.Journal of Physiology2014
25236710Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.Circ Arrhythm Electrophysiol2014
24949568CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Journal of Molecular and Cellular Cardiology2014
24848360In vivo selective expression of thyroid hormone receptor α1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice.American Journal of Physiology - Regulatory Integrative and Comparative Physiology2014
24575042CaMKIIdelta subtypes: localization and function.Frontiers in Pharmacology2014
24790104The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.Journal of Biological Chemistry2014
23072745PHLPP1 gene deletion protects the brain from ischemic injury.Journal of Cerebral Blood Flow and Metabolism2013
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