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Author Details

Andrew Wakeham
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
1989
135
79
PMIDPaper TitleJournal TitlePublished Year
36528755Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis.Cell Death Differ2023
37729199HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.Proc Natl Acad Sci U S A2023
37640929Tumor-specific cholinergic CD4<sup>+</sup> T lymphocytes guide immunosurveillance of hepatocellular carcinoma.Nat Cancer2023
37493438Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.J Immunol2023
36370712The transcription factor IRF2 drives interferon-mediated CD8<sup>+</sup> T cell exhaustion to restrict anti-tumor immunity.Immunity2022
33444287Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.J Clin Invest2021
33826883Influence of the microenvironment on modulation of the host response by typhoid toxin.Cell Rep2021
33866248Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer.Breast2021
34059798The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.Cell Death Differ2021
33254233IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis.Blood2021
32142668Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.Cancer Cell2020
34124690Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs.Nat Cancer2020
30733286AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.Proc Natl Acad Sci U S A2019
31213601Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.Nat Commun2019
31481706Author Correction: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.Nat Commun2019
30770442Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.Proc Natl Acad Sci U S A2019
30733420Choline acetyltransferase-expressing T cells are required to control chronic viral infection.Science2019
28011762IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.Proc Natl Acad Sci U S A2017
28084302K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.Nat Commun2017
29158347Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. <i>Science</i>. 1997. 275: 540-543.J Immunol2017
26787889Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.Proc Natl Acad Sci U S A2016
27956631The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.Proc Natl Acad Sci U S A2016
27424808Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Cancer Cell2016
27184401Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.Cell Stem Cell2016
25583492Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.Proc Natl Acad Sci U S A2015
25882048Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.Cell Death Differ2015
25620030Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.Cancer Cell2015
23435421PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.Oncogene2014
25272040XB130 deficiency affects tracheal epithelial differentiation during airway repair.PLoS One2014
24567396Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.Proc Natl Acad Sci U S A2014
24656129Largen: a molecular regulator of mammalian cell size control.Mol Cell2014
24449892TAp73 is required for spermatogenesis and the maintenance of male fertility.Proc Natl Acad Sci U S A2014
23708664Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells.Oncogene2014
23146906Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model.Oncogene2013
23857982BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.J Exp Med2013
23699408Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.Genes Dev2013
23179078ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.Nat Immunol2013
23359703Involvement of Toso in activation of monocytes, macrophages, and granulocytes.Proc Natl Acad Sci U S A2013
22213803The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.J Exp Med2012
22763442IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.Nature2012
22863785Bat3 promotes T cell responses and autoimmunity by repressing Tim-3â¿¿mediated cell death and exhaustion.Nat Med2012
22925884D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.Genes Dev2012
22246778iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.Science2012
2120588714-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.Proc Natl Acad Sci U S A2011
21576264Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.Genes Dev2011
21636789Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.Proc Natl Acad Sci U S A2011
21445275Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.PLoS One2011
20133759HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.Proc Natl Acad Sci U S A2010
21049064Generation and characterization of the Anp32e-deficient mouse.PLoS One2010
20543135Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.Proc Natl Acad Sci U S A2010
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Collaborators

Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 116
Andrew J Elia
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 39
Chiara Gorrini
Division of Clinical Studies, The Institute of Cancer Research
Co-authored papers 12
Thorsten Berger
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
David W Cescon
Princess Margaret Cancer Centre
Co-authored papers 10
Razqallah Hakem
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 8
Christopher J Paige
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Rama Khokha
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Anne Hakem
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Yi Zheng
Children's Hospital Research Foundation
Co-authored papers 5
Lea Harrington
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 4
Evan F Lind
Oregon Health & Science University
Co-authored papers 4
Jacqueline M Mason
Campbell Family Institute for Breast Cancer Research, University Health Network
Co-authored papers 4
Jeremy A Squire
University of Sao Paulo
Co-authored papers 4
Paola Cappello
University of Turin
Co-authored papers 3
Heiko Blaser
Princess Margaret Cancer Centre
Co-authored papers 3
Janet Rossant
The Hospital for Sick Children
Co-authored papers 3
Susan J Done
University Health Network
Co-authored papers 3
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 3
Andrea Jurisicova
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 3
Paul D Waterhouse
Princess Margaret Cancer Centre/University Health Network
Co-authored papers 3
Garry P Nolan
Stanford University School of Medicine
Co-authored papers 2
Igor Jurisica
Schroeder Arthritis Institute
Co-authored papers 2
Otto Sanchez
Ontario Tech University
Co-authored papers 2
Jennifer Cruickshank
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Robert G Bristow
University of Toronto
Co-authored papers 2
Linda Z Penn
University of Toronto
Co-authored papers 2
William L Stanford
Ottawa Hospital Research Institute
Co-authored papers 2
Tony Pawson
Co-authored papers 2
Hal K Berman
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Release 1.2