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Author Details

Robert W Mahley
Gladstone Institute of Neurological Disease
1968
313
123
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37791598APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.Alzheimers Dement2024
37791598APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.Alzheimers Dement2024
36753858Apolipoprotein E4 targets mitochondria and the mitochondria-associated membrane complex in neuropathology, including Alzheimer's disease.Curr Opin Neurobiol2023
37957317The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.Nat Neurosci2023
37019383Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.Mol Cell Proteomics2023
36753858Apolipoprotein E4 targets mitochondria and the mitochondria-associated membrane complex in neuropathology, including Alzheimer's disease.Curr Opin Neurobiol2023
37957317The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.Nat Neurosci2023
37019383Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.Mol Cell Proteomics2023
36453989A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE.Nucleic Acids Res2022
36453989A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE.Nucleic Acids Res2022
30883359Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.J Alzheimers Dis2019
30883359Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.J Alzheimers Dis2019
28062606Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases.Clin Chem2017
28062606Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases.Clin Chem2017
27277824Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.J Mol Med (Berl)2016
27277824Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.J Mol Med (Berl)2016
27174096Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.Arterioscler Thromb Vasc Biol2016
27654912The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.Nature2016
27654912The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.Nature2016
27174096Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.Arterioscler Thromb Vasc Biol2016
25173806Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Neurobiol Dis2014
25230663Ancient human genomes suggest three ancestral populations for present-day Europeans.Nature2014
25173806Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Neurobiol Dis2014
25230663Ancient human genomes suggest three ancestral populations for present-day Europeans.Nature2014
23618992Shinya Yamanaka, M.D., Ph.D. - 2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists.Anadolu Kardiyol Derg2013
23618992Shinya Yamanaka, M.D., Ph.D. - 2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists.Anadolu Kardiyol Derg2013
22158868Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.J Biol Chem2012
22479202Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.PLoS Genet2012
22959699Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.Alzheimers Dement2012
22332727Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations.Ann Hum Genet2012
23013167Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.J Med Chem2012
23217737Apolipoprotein e sets the stage: response to injury triggers neuropathology.Neuron2012
22238593A genome-wide association search for type 2 diabetes genes in African Americans.PLoS One2012
22158868Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.J Biol Chem2012
23217737Apolipoprotein e sets the stage: response to injury triggers neuropathology.Neuron2012
22959699Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.Alzheimers Dement2012
23013167Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.J Med Chem2012
22479202Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.PLoS Genet2012
22238593A genome-wide association search for type 2 diabetes genes in African Americans.PLoS One2012
22332727Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations.Ann Hum Genet2012
21118811Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.J Biol Chem2011
21488854Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks.Ann Hum Genet2011
21118811Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.J Biol Chem2011
21454574Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.J Biol Chem2011
21488854Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks.Ann Hum Genet2011
21454574Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.J Biol Chem2011
19734193Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.J Lipid Res2010
19734193Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.J Lipid Res2010
20864672Genetic variants influencing circulating lipid levels and risk of coronary artery disease.Arterioscler Thromb Vasc Biol2010
20081858New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.Nat Genet2010
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Regeneron Pharmaceuticals Inc.
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NIH/National Institute of Ageing
Co-authored papers 5
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Vagelos College of Physicians and Surgeons, Columbia University
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