Skip to Main Content

Author Details

Ruth Luthi-Carter
University of Leicester
1992
82
48
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36606207Tubulin Isotypes and Posttranslational Modifications in Vascular Dementia and Alzheimer's Disease.J Alzheimers Dis Rep2022
34776926Tubulin and Tubulin Posttranslational Modifications in Alzheimer's Disease and Vascular Dementia.Front Aging Neurosci2021
33305259Longitudinal expression changes are weak correlates of disease progression in Huntington's disease.Brain Commun2020
27404284Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.Transl Psychiatry2016
26428929Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models.J Mol Med (Berl)2016
27427231SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.Cell Chem Biol2016
25620908Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis.Front Neurosci2015
24459107HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.Brain2014
24674959Involvement of autophagy in hypoxic-excitotoxic neuronal death.Autophagy2014
24436303A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Hum Mol Genet2014
23349832MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.PLoS One2013
25062675Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease.J Huntingtons Dis2013
24900595Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity.ACS Med Chem Lett2013
24278330HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.PLoS One2013
24302884HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.PLoS Biol2013
23392662MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.J Neurosci2013
23516279Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.J Neurosci2013
23301037An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.PLoS One2013
21820514What have we learned from gene expression profiles in Huntington's disease?Neurobiol Dis2012
22917585Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases.Brain Res2012
22848491Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.PLoS One2012
21177255In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Hum Mol Genet2011
22179319Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.Nat Med2011
21779398Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation.PLoS One2011
21785217Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.J Clin Invest2011
21888376Synchrotron infrared microspectroscopy detecting the evolution of Huntington's disease neuropathology and suggesting unique correlates of dysfunction in white versus gray brain matter.Anal Chem2011
21983921Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain.Nat Methods2011
21370928A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.ACS Chem Biol2011
21334439Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease.Neurobiol Dis2011
20089533Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.Hum Mol Genet2010
20720508Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.J Neuropathol Exp Neurol2010
20470891Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons.Mol Cell Neurosci2010
20613636Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.J Neuropathol Exp Neurol2010
20624994Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments.J Pharmacol Exp Ther2010
20237298Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.FASEB J2010
20378838SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.Proc Natl Acad Sci U S A2010
20375136Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease.Brain2010
19934114Expression analysis of novel striatal-enriched genes in Huntington disease.Hum Mol Genet2010
19043139A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease.Mol Cell Proteomics2009
19686238Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.J Neurochem2009
19334076Sustained effects of nonallele-specific Huntingtin silencing.Ann Neurol2009
19390590Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation.PLoS One2009
19240038Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration.J Biol Chem2009
19022249Implication of the JNK pathway in a rat model of Huntington's disease.Exp Neurol2009
17905594Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.Neurobiol Dis2008
18820996Biological and potential therapeutic roles of sirtuin deacetylases.Cell Mol Life Sci2008
18815258Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.J Neurosci2008
18694930The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.J Biol Chem2008
18316204Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivision.Mol Cell Neurosci2008
18201381Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'.BMC Bioinformatics2008
  • 1 - 50 of 82

Recommended Authors

Jeha Jeon
Department of Psychiatry and McLean Hospital, Harvard Medical School
Career Start Year 2014
Number of shared co-authors 0
Mary H Wertz
Broad Institute, Picower Institute for Learning and Memory
Career Start Year 2007
Number of shared co-authors 0
Laura Ru??
Department of Pharmaceutical and Pharmacological Sciences
Career Start Year 2007
Number of shared co-authors 0
Prianka Chawla
Center for Regenerative Therapies Dresden, Technische Universitat Dresden
Career Start Year 2007
Number of shared co-authors 7
Vivek Swarup
David Geffen School of Medicine, University of California los angeles
Career Start Year 2007
Number of shared co-authors 2
Kelly E Glajch
Neurodegenerative Diseases Research Unit
Career Start Year 2006
Number of shared co-authors 7
Yaqiao Li
Harvard Medical School
Career Start Year 2005
Number of shared co-authors 1
Mina Ryten
UCL Great Ormond Street Institute of Child Health, University College London
Career Start Year 2001
Number of shared co-authors 3
Byoung-Il Bae
University of Connecticut School of Medicine
Career Start Year 2000
Number of shared co-authors 0
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Career Start Year 1999
Number of shared co-authors 2
Jan Mulder
Karolinska Institute
Career Start Year 1999
Number of shared co-authors 0
Christopher Dirk Keene
University of Washington
Career Start Year 1998
Number of shared co-authors 2
Suman Jayadev
University of Washington
Career Start Year 1995
Number of shared co-authors 2
Hyemyung Seo
Center for Bionano Intelligence Education and Research, Hanyang University
Career Start Year 1995
Number of shared co-authors 1
Claudia Crosio
University of Sassari
Career Start Year 1994
Number of shared co-authors 0
Pamela J McMillan
University of Washington
Career Start Year 1993
Number of shared co-authors 0
Sandrine Humbert
Grenoble Institut Neurosciences, INSERM, Universite Grenoble Alpes
Career Start Year 1992
Number of shared co-authors 0
Li-Huei Tsai
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Career Start Year 1991
Number of shared co-authors 1
Kwang-Soo Kim
McLean Hospital and Program in Neuroscience, Harvard Medical School
Career Start Year 1991
Number of shared co-authors 0
Lisa M Ellerby
Buck Institute for Research on Aging
Career Start Year 1990
Number of shared co-authors 5
Eric J Huang
University of California san francisco
Career Start Year 1990
Number of shared co-authors 2
Stefano Gustincich
Istituto Italiano di Tecnologia
Career Start Year 1989
Number of shared co-authors 1
Valina L Dawson
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Career Start Year 1988
Number of shared co-authors 2
Gwenn A Garden
University of Washington School of Medicine
Career Start Year 1988
Number of shared co-authors 0
Steven Finkbeiner
J. David Gladstone Institutes
Career Start Year 1988
Number of shared co-authors 3
Jonathan D Cooper
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Career Start Year 1987
Number of shared co-authors 1
Eliezer Masliah
National Institute On Aging
Career Start Year 1986
Number of shared co-authors 5
Ted M Dawson
Johns Hopkins University School of Medicine
Career Start Year 1983
Number of shared co-authors 2
Virginia M-Y Lee
Perelman School of Medicine at the University of Pennsylvania
Career Start Year 1977
Number of shared co-authors 4
William C Mobley
University of California San Diego
Career Start Year 1973
Number of shared co-authors 2

Collaborators

Alexandre Kuhn
Institute of Biotechnology, University of Lausanne
Co-authored papers 16
Joseph T Coyle
Harvard Medical School and McLean Hospital
Co-authored papers 14
James M Olson
Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 8
Jang-Ho J Cha
Novartis Institutes for Biomedical Research
Co-authored papers 7
Darlene R Goldstein
Co-authored papers 6
Charles Kooperberg
Co-authored papers 6
Mauro Delorenzi
Co-authored papers 5
David G Standaert
University of Alabama at Birmingham
Co-authored papers 3
Dmitriy Leyfer
Boston University
Co-authored papers 3
Ghazaleh Sadri-Vakili
Sean M. Healey & AMG Center for ALS at Mass General
Co-authored papers 3
Leslie M Thompson
Co-authored papers 3
Michael R Hayden
Co-authored papers 3
Aaron K Aragaki
Co-authored papers 2
Tim Clark
Co-authored papers 2
Sudeshna Das
Massachusetts General Hospital
Co-authored papers 2
Timothy Clark (CM4AI)
University of Virginia
Co-authored papers 2
Neil W Kowall
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 2
Daniel H Geschwind
University of California los angeles
Co-authored papers 2
Karen N McFarland
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 2
Tingting Sun
Department of Food Engineering, Harbin University
Co-authored papers 2
Giovanni Coppola
David Geffen School of Medicine, University of California los angeles
Co-authored papers 2
Gavin R Sangrey
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 2
Thierry Sengstag
University of Basel
Co-authored papers 2
Judit Pallos
Jungers Center for Neurosciences, Oregon Health and Science University
Co-authored papers 2
Steven M Hersch
Inc. University Avenue
Co-authored papers 2
Eva Xia
Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 2
Valentina Escott-Price
Co-authored papers 1
Ryan G Lim
Co-authored papers 1
Peter Holmans
Co-authored papers 1
Mee-Ohk Kim
University of California san francisco
Co-authored papers 1
Release 1.2