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Author Details

David E Nichols
Eshelman School of Pharmacy, University of North Carolina
1971
292
57
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37130596Remove barriers to clinical research for schedule 1 drugs with therapeutic potential.BMJ2023
36087581Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.Neuron2022
35401275Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated.Front Psychiatry2022
35699130Preface to the special issue "Psychedelics and Neurochemistry".J Neurochem2022
33285579The History of Psychedelics in Psychiatry.Pharmacopsychiatry2021
34555409The effects of acute stress on attentional networks and working memory in females.Physiol Behav2021
34151472Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning.Depress Anxiety2021
34340176BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall.Behav Res Ther2021
32398764Psilocybin: from ancient magic to modern medicine.J Antibiot (Tokyo)2020
32946782Structure of a Hallucinogen-Activated Gq-Coupled 5-HT<sub>2A</sub> Serotonin Receptor.Cell2020
30298278Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA).Psychopharmacology (Berl)2019
30252437Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models.ACS Chem Neurosci2019
31303095Microdosing psychedelics: More questions than answers? An overview and suggestions for future research.J Psychopharmacol2019
31297368Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation <i>in vitro</i>.Front Bioeng Biotechnol2019
30443792Correction to: Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA).Psychopharmacology (Berl)2019
28585392Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775).Drug Test Anal2018
29991342Author's reply.J Psychopharmacol2018
28401524Chemistry and Structure-Activity Relationships of Psychedelics.Curr Top Behav Neurosci2018
29408722Is LSD toxic?Forensic Sci Int2018
29461039Dark Classics in Chemical Neuroscience: Lysergic Acid Diethylamide (LSD).ACS Chem Neurosci2018
29095071N,N-dimethyltryptamine and the pineal gland: Separating fact from myth.J Psychopharmacol2018
27265891Return of the lysergamides. Part II: Analytical and behavioural characterization of N<sup>6</sup> -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ).Drug Test Anal2017
28129538Crystal Structure of an LSD-Bound Human Serotonin Receptor.Cell2017
28500275Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation.Proc Natl Acad Sci U S A2017
28342178Return of the lysergamides. Part III: Analytical characterization of N[6] -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD).Drug Test Anal2017
28143767Striatal dopamine D1 receptor suppression impairs reward-associative learning.Behav Brain Res2017
28947075Psychedelic Drugs in Biomedicine.Trends Pharmacol Sci2017
28019026Psychedelics as Medicines: An Emerging New Paradigm.Clin Pharmacol Ther2017
26841800Psychedelics.Pharmacol Rev2016
26340558Comparison of electrospray ionization and atmospheric pressure photoionization liquid chromatography mass spectrometry methods for analysis of ergot alkaloids from endophyte-infected sleepygrass (Achnatherum robustum).J Pharm Biomed Anal2016
27071089Neural correlates of the LSD experience revealed by multimodal neuroimaging.Proc Natl Acad Sci U S A2016
25320048The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.J Pharmacol Exp Ther2015
26212274Analytical characterization of bioactive N-benzyl-substituted phenethylamines and 5-methoxytryptamines.Rapid Commun Mass Spectrom2015
25909758Neuroreceptor activation by vibration-assisted tunneling.Sci Rep2015
25547199N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues.ACS Chem Neurosci2015
24704148Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia.Neuropharmacology2014
24830182The Heffter Research Institute: past and hopeful future.J Psychoactive Drugs2014
23336049Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands.ACS Chem Neurosci2013
24149187New victims of current drug laws.Nat Rev Neurosci2013
23756634Effects of Schedule I drug laws on neuroscience research and treatment innovation.Nat Rev Neurosci2013
22176338A reported "new synthesis of lysergic acid" yields only the derailment product: methyl 5-methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate.Org Lett2012
23209503trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family.Beilstein J Org Chem2012
23018094Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine Dâ¿¿ receptor-selective full agonist ligand.Bioorg Med Chem2012
22222862Comparison of the D⿁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease.Psychopharmacology (Berl)2012
22222861Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor.Psychopharmacology (Berl)2012
22334593Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists.Mol Pharmacol2012
22204903Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.Eur J Med Chem2012
21209630Legal highs: the dark side of medicinal chemistry.Nature2011
21862338Assessment of dopamine D⿁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.Bioorg Med Chem2011
21827831A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference.Neurosci Lett2011
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Collaborators

National Institute of Environmental Health Sciences
Co-authored papers 11
Purdue University
Co-authored papers 9
UNC Chapel Hill School of Medicine
Co-authored papers 9
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University
Co-authored papers 7
Co-authored papers 5
University of California San Diego, VA San Diego Healthcare System
Co-authored papers 4
University of Pittsburgh
Co-authored papers 3
Stanford University School of Medicine
Co-authored papers 2
Co-authored papers 2
University of Pittsburgh School of Medicine
Co-authored papers 2
Stanford University School of Medicine
Co-authored papers 2
Stanford University School of Medicine
Co-authored papers 2
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
University of North Carolina School of Medicine
Co-authored papers 2
University of North Carolina School of Medicine
Co-authored papers 2
University of North Carolina at Chapel Hill
Co-authored papers 2
Stanford University School of Medicine
Co-authored papers 1
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Lawrence Berkeley National Laboratory
Co-authored papers 1
Co-authored papers 1
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
University of North Carolina School of Medicine
Co-authored papers 1
University of North Carolina School of Medicine
Co-authored papers 1
Duke University
Co-authored papers 1
University of North Carolina at Chapel Hill
Co-authored papers 1
Institute for Computational Biomedicine
Co-authored papers 1