Author details

Full Name

Mehmet Kesimer

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37196698	Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier.		2023
36372912	Vaping additives cannabinoid oil and vitamin E acetate adhere to and damage the human airway epithelium.	Journal of Applied Toxicology	2023
38016030	Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis (NCFB).		2023
35023825	Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of <i>MUC5B</i>.	Am J Respir Crit Care Med	2022
35699372	Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium.	mBio	2022
35938865	Mucins MUC5AC and MUC5B in the Airways: MUCing around Together.	American Journal of Respiratory and Critical Care Medicine	2022
35486871	Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.	American Journal of Respiratory Cell and Molecular Biology	2022
35363522	Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.	Science advances	2022
34172469	Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties hydration.	European Respiratory Journal	2022
34091707	Is bipolar hemiarthroplasty an appropriate type of hip articulation following proximal femoral or total femoral resections for musculoskeletal malignancies?	Archives of Orthopaedic and Trauma Surgery	2022
33315805	Effect of rotational deformities after pediatric femoral fracture on clinical outcome.	Journal of Pediatric Orthopaedics Part B	2022
34801592	Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD.	Chest	2022
35239513	Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.	Journal of Clinical Investigation	2022
34548396	Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.	Proc Natl Acad Sci U S A	2021
34231541	Efficacy and Safety of Tranexamic Acid in Resection and Endoprosthetic Reconstruction of Distal Femoral Osteosarcomas in Children: A Retrospective Cohort Study.	Journal of Pediatric Orthopaedics	2021
34058148	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	Lancet Respiratory Medicine,The	2021
34306544	Dorsal or Lateral Approach for Intramedullary Nailing Using Kirschner Wire in Pediatric Radius Diaphyseal Fractures: Does it really matter?	Indian Journal of Orthopaedics	2021
33083824	Membrane-bound mucins of the airway mucosal surfaces are densely decorated with keratan sulfate: revisiting their role in the Lung's innate defense.	Glycobiology	2021
34853335	Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease.	Sci Rep	2021
34613844	Culture with apically applied healthy or disease sputum alters the airway surface liquid proteome and ion transport across human bronchial epithelial cells.	American Journal of Physiology - Cell Physiology	2021
32877614	Cigarillos Compromise the Mucosal Barrier and Protein Expression in Airway Epithelia.	American Journal of Respiratory Cell and Molecular Biology	2020
32601108	Human Fallopian Tube Epithelial Cell Culture Model To Study Host Responses to Chlamydia trachomatis Infection.	Infection and Immunity	2020
31199664	Another Warning Sign: High Nicotine Content in Electronic Cigarettes Disrupts Mucociliary Clearance, the Essential Defense Mechanism of the Lung.	American Journal of Respiratory and Critical Care Medicine	2019
31570524	The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion.	Journal of Biological Chemistry	2019
30352166	Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.	American Journal of Respiratory and Critical Care Medicine	2019
30230353	Intercellular Communication between Airway Epithelial Cells Is Mediated by Exosome-Like Vesicles.	Am J Respir Cell Mol Biol	2019
31524632	IL-1Î² dominates the promucin secretory cytokine profile in cystic fibrosis.	Journal of Clinical Investigation	2019
31389736	Endotracheal tube mucus as a source of airway mucus for rheological study.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2019
30712400	Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.	COPD	2018
28736267	Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.	J Allergy Clin Immunol	2018
28982737	Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2018
29053025	E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion.	American Journal of Respiratory and Critical Care Medicine	2018
29890087	Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration.	FASEB Journal	2018
30190268	SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration.	European Respiratory Journal	2018
30130124	Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease.	American Journal of Respiratory and Critical Care Medicine	2018
29099608	Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia.	American Journal of Respiratory and Critical Care Medicine	2018
29406779	At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.	American Journal of Respiratory and Critical Care Medicine	2018
29082098	Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.	Biomedical Optics Express	2017
28447619	Little Cigars are More Toxic than Cigarettes and Uniquely Change the Airway Gene and Protein Expression.	Scientific Reports	2017
28877023	Airway Mucin Concentration as a Marker of Chronic Bronchitis.	New England Journal of Medicine	2017
28352653	Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.	JCI insight	2017
27831803	Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.	Annals of the American Thoracic Society	2016
27072609	The innate immune properties of airway mucosal surfaces are regulated by dynamic interactions between mucins and interacting proteins: the mucin interactome.	Mucosal Immunology	2016
27708065	Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.	Sci Transl Med	2016
26414376	Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs.	PLoS ONE	2015
25909230	The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.	Am J Respir Crit Care Med	2015
25823850	Physical characterization and profiling of airway epithelial derived exosomes using light scattering.	Methods	2015
24892808	Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.	Journal of Clinical Investigation	2014
24124190	Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.	Am J Physiol Lung Cell Mol Physiol	2013
22929560	Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.	Mucosal Immunol	2013