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Author Details

Christopher J Westlake
Center for Cancer Research
1998
44
24
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37164540Multi-color live-cell fluorescence imaging of primary ciliary membrane assembly and dynamics.Methods Cell Biol2023
35351373Ciliogenesis membrane dynamics and organization.Semin Cell Dev Biol2023
34787650CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis.J Cell Biol2022
35767367Intracellular connections between basal bodies promote the coordinated behavior of motile cilia.Mol Biol Cell2022
35201641Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery.EMBO Rep2022
34241634A ciliopathy complex builds distal appendages to initiate ciliogenesis.J Cell Biol2021
37288144Live-cell fluorescence imaging of ciliary dynamics.Biophys Rep2021
33718933Recent advances in understanding assembly of the primary cilium membrane.Fac Rev2021
33561422RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.Dev Cell2021
34509474The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress.J Biol Chem2021
34453712CLEM Characterization of Rab8 and Associated Membrane Trafficking Regulators at Primary Cilium Structures.Methods Mol Biol2021
34559995A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.Am J Hum Genet2021
30683896Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.Nat Commun2019
31467083The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.J Biol Chem2019
31204173Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.Dev Cell2019
31220269Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes.Hum Mol Genet2019
30808747M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.Proc Natl Acad Sci U S A2019
30783093Publisher Correction: Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.Nat Commun2019
29298421Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.Cell Rep2018
29259016Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.Cancer Res2018
28700940In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.Cell Rep2017
25812525Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.Nat Cell Biol2015
26292321Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly.J Virol2015
25686250Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.Nat Cell Biol2015
24648346CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells.Cancer Res2014
25313408Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation.J Cell Biol2014
25143588Primary cilia signaling mediates intraocular pressure sensation.Proc Natl Acad Sci U S A2014
24648492Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.Mol Biol Cell2014
24046448A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.J Cell Sci2013
21273506Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.Proc Natl Acad Sci U S A2011
22035799Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.Chem Biol2011
18381564Identification of regions required for apical membrane localization of human multidrug resistance protein 2.Mol Pharmacol2008
17229837Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.Proc Natl Acad Sci U S A2007
17574030A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.Cell2007
16816140Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Physiol Rev2006
15772158Role of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking.Mol Biol Cell2005
15755910Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1).Mol Pharmacol2005
15459206Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.J Biol Chem2004
14640677Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3.Biochemistry2003
12882957Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).J Biol Chem2003
12138119Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.J Biol Chem2002
11507101Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein.J Biol Chem2001
11500505Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.J Biol Chem2001
9553138Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4.J Biol Chem1998
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Collaborators

Quanlong Lu
Brody School of Medicine, East Carolina University
Co-authored papers 13
Peter K Jackson
Stanford University School of Medicine, Center for Clinical Sciences Research
Co-authored papers 5
Vijay Walia
National Center for Toxicological Research
Co-authored papers 5
Deborah K Morrison
Center for Cancer Research, National Cancer Institute-Frederick
Co-authored papers 3
Kedar Narayan
Co-authored papers 3
Val C Sheffield
Carver College of Medicine, University of Iowa
Co-authored papers 2
Gloria M Petersen
Mayo Clinic
Co-authored papers 2
Brian P Brooks
Co-authored papers 2
Rytis Prekeris
Co-authored papers 2
Kunio Nagashima
Co-authored papers 2
Timothy W Corson
Indiana University School of Medicine
Co-authored papers 1
Erica Stevenson
University of California san francisco
Co-authored papers 1
Jeremy F Reiter
Cardiovascular Research Institute
Co-authored papers 1
Rupa Sridharan
Wisconsin Institute for Discovery, University of Wisconsin-Madison
Co-authored papers 1
Ronna Hertzano
University of Maryland School of Medicine
Co-authored papers 1
Artur V Cideciyan
Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Brenda Y Hernandez
University of Hawaii Cancer Center
Co-authored papers 1
Jos?? Manuel Garc??a-Verdugo
Cavanilles Institute, University of Valencia
Co-authored papers 1
Nathan Hotaling
National Center for Advancing Translational Sciences, National Institutes of Health
Co-authored papers 1
Stephen J Chanock
National Cancer Institute, National Institutes of Health
Co-authored papers 1
Kris Ylaya
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
Andrew A Peden
University of Sheffield
Co-authored papers 1
Jianxin Shi
National Cancer Institute, 9609 Medical Center Drive
Co-authored papers 1
Wendy Cozen
Co-authored papers 1
Anand Swaroop
National Eye Institute, National Institutes of Health
Co-authored papers 1
Snorri S Thorgeirsson
Co-authored papers 1
May Christine V Malicdan
National Human Genome Research Institute, National Institutes of Health
Co-authored papers 1
Bo Huang
University of California san francisco
Co-authored papers 1
Samuel G Jacobson
Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Stephen M Hewitt
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