Author details

Full Name

Brandon F Keele

Affiliation

ORCID

Career Start Year

2001

Papers

199

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36848230	Experimental bacterial dysbiosis with consequent immune alterations increase intrarectal SIV acquisition susceptibility.	Cell Rep	2023
37747933	CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.	PLoS Pathog	2023
38014094	TGF-Î² blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs .		2023
37801446	Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication.	PLoS Pathog	2023
37418480	Correction: Tracking the Luminal Exposure and Lymphatic Drainage Pathways of Intravaginal and Intrarectal Inocula Used in Nonhuman Primate Models of HIV Transmission.	PLoS One	2023
36909458	CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques.	bioRxiv	2023
36511699	Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events.		2023
37399208	Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques.		2023
37398418	Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques.	bioRxiv	2023
37075022	Correction: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.	PLoS Pathog	2023
37322122	Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV.		2023
37126090	Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.	AIDS Res Hum Retroviruses	2023
36690860	CD8 lymphocytes do not impact SIV reservoir establishment under ART.		2023
34986348	Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys.	Cell Rep	2022
35714165	A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection.	PLoS Pathog	2022
36344847	Cryo-EM structures of prefusion SIV envelope trimer.	Nat Struct Mol Biol	2022
35736240	Transcription Start Site Heterogeneity and Preferential Packaging of Specific Full-Length RNA Species Are Conserved Features of Primate Lentiviruses.	Microbiology spectrum	2022
35608873	Systematic analysis of Kaposi's sarcoma (KS)-associated herpesvirus genomes from a KS case-control study in Cameroon: Evidence of dual infections but no association between viral sequence variation and KS risk.	International Journal of Cancer	2022
33957772	Lack of Specific Regulatory T Cell Depletion and Cytoreduction Associated with Extensive Toxicity After Administration of Low and High Doses of Cyclophosphamide.	AIDS Research and Human Retroviruses	2022
34855793	The mucosal barrier and anti-viral immune responses can eliminate portions of the viral population during transmission and early viral growth.	PLoS ONE	2021
33970966	Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.	PLoS Pathog	2021
33630764	CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification.	J Clin Invest	2021
33465055	Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.	J Clin Invest	2021
33946976	CpG Methylation Profiles of HIV-1 Pro-Viral DNA in Individuals on ART.	Viruses	2021
34143853	Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir.	PLoS Pathog	2021
33658341	New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure.	J Virol	2021
33554060	Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.	iScience	2021
34408080	Blocking Î±Î² integrin delays viral rebound in SHIV-infected macaques treated with anti-HIV broadly neutralizing antibodies.	Science Translational Medicine	2021
33110078	Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation.	Nature Communications	2020
31969438	Long-Acting Rilpivirine (RPV) Preexposure Prophylaxis Does Not Inhibit Vaginal Transmission of RPV-Resistant HIV-1 or Select for High-Frequency Drug Resistance in Humanized Mice.	Journal of Virology	2020
31843933	Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape.	Proc Natl Acad Sci U S A	2020
31581292	Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains.	J Infect Dis	2020
32119719	African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity.	PLoS Pathog	2020
34211736	Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by whole-genome sequence analysis of effusion samples.	Virus Evolution	2020
33205023	Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies.	iScience	2020
32811309	Impact of fluctuation in frequency of human immunodeficiency virus/simian immunodeficiency virus reactivation during antiretroviral therapy interruption.		2020
33016926	HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus.	J Clin Invest	2020
32614969	Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.	Blood	2020
31048506	Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host.	Proc Natl Acad Sci U S A	2019
31650954	Predictors of SIV recrudescence following antiretroviral treatment interruption.	Elife	2019
31597776	Evaluating the Intactness of Persistent Viral Genomes in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Initiating Antiretroviral Therapy within One Year of Infection.	J Virol	2019
31597757	<i>In Vivo</i> Validation of the Viral Barcoding of Simian Immunodeficiency Virus SIVmac239 and the Development of New Barcoded SIV and Subtype B and C Simian-Human Immunodeficiency Viruses.	J Virol	2019
31632364	HIV Infected T Cells Can Proliferate <i>in vivo</i> Without Inducing Expression of the Integrated Provirus.	Front Microbiol	2019
31776247	Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.	Proc Natl Acad Sci U S A	2019
31761718	Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.		2019
30381490	Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes.	J Virol	2019
30753366	Insertion as a Resistance Mechanism Against Integrase Inhibitors in Several Retroviruses.	Clinical Infectious Diseases	2019
31488690	Blocking Î±<sub>4</sub>Î²<sub>7</sub> integrin binding to SIV does not improve virologic control.	Science	2019
31488688	Evaluation of an antibody to Î±<sub>4</sub>Î²<sub>7</sub> in the control of SIVmac239-<i>nef-stop</i> infection.	Science	2019
31488689	Lack of therapeutic efficacy of an antibody to Î±<sub>4</sub>Î²<sub>7</sub> in SIVmac251-infected rhesus macaques.	Science	2019