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Author Details

Itay Tirosh
Weizmann Institute of Medical Sciences
2005
83
46
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37012457Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma.Nat Genet2023
37914930Glioma synapses recruit mechanisms of adaptive plasticity.Nature2023
37853118Clinical trial links oncolytic immunoactivation to survival in glioblastoma.Nature2023
37258682Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours.Nature2023
37449843Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA-Associated Pancreatic Cancer in the Clinical and Preclinical Setting.Cancer Discov2023
36123598Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis.Genome Med2022
35411083Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis.Nat Cell Biol2022
35537413An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes.Cancer Cell2022
35624136Stochastic transitions as a major source of cancer heterogeneity.Nat Rev Genet2022
36224665Correction: Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis.Genome Med2022
33392634MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression.J Mol Med (Berl)2021
33720339Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.Blood Adv2021
33592174Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.Cell2021
33619381A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.Nat Metab2021
33811126Decoding Cancer Biology One Cell at a Time.Cancer Discov2021
33799782Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma.Cancers (Basel)2021
34087162Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.Cancer Cell2021
33972543Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis.Nat Commun2021
32396858The Glioma Stem Cell Model in the Era of Single-Cell Genomics.Cancer Cell2020
33128048Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.Nat Genet2020
32855387Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.Nat Commun2020
32572264A single-cell landscape of high-grade serous ovarian cancer.Nat Med2020
32958684Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma.J Immunother Cancer2020
32841535Nasopharyngeal carcinoma joins the single-cell party.Cancer Commun (Lond)2020
32142659Tackling the Many Facets of Glioblastoma Heterogeneity.Cell Stem Cell2020
30568305Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.Nature2019
31704557Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis.Oral Oncol2019
31689639Single-cell sequencing and its applications in head and neck cancer.Oral Oncol2019
31299208Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges.Mol Cell2019
29016805Dissecting human gliomas by single-cell RNA sequencing.Neuro Oncol2018
30209080Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma.Cancer Discov2018
30250901Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer.Mol Cell Oncol2018
30392957T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.Cell2018
30388455A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.Cell2018
29674595Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.Science2018
29681511A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.Cancer Cell2018
28666115IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.Cell2017
28360267Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.Science2017
28482897Challenges and emerging directions in single-cell analysis.Genome Biol2017
29232558High-throughput Phenotyping of Lung Cancer Somatic Mutations.Cancer Cell2017
29198524Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.Cell2017
29051390Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.Genes Dev2017
29144463A single-cell survey of the small intestinal epithelium.Nature2017
29190685Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.PLoS Biol2017
27478040High-throughput Phenotyping of Lung Cancer Somatic Mutations.Cancer Cell2016
27806376Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.Nature2016
27684187Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.Cell Syst2016
27124452Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.Science2016
25748434Chromatin mediation of a transcriptional memory effect in yeast.G3 (Bethesda)2015
26430063Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.Genome Res2015
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Collaborators

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Broad Institute of MIT and Harvard
Co-authored papers 22
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Broad Institute of MIT and Harvard
Co-authored papers 20
Orit Rozenblatt-Rosen
Co-authored papers 15
Alex K Shalek
Institute for Medical Engineering & Science, Massachusetts Institute of Technology
Co-authored papers 7
Bradley E Bernstein
Broad Institute of MIT and Harvard
Co-authored papers 7
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 7
David N Louis
Co-authored papers 6
Gad Getz
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 6
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 5
Brian V Nahed
Harvard Medical School
Co-authored papers 4
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Broad Institute of Harvard and MIT
Co-authored papers 4
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Co-authored papers 4
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Massachusetts General Hospital and Harvard Medical School
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Danielle Dionne
Co-authored papers 4
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Co-authored papers 4
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Brigham and Women's Hospital
Co-authored papers 3
Michael S Cuoco
Co-authored papers 3
Federica Piccioni
Co-authored papers 3
David L Lahr
Co-authored papers 3
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 3
Aravind Subramanian
Co-authored papers 3
Rahul Satija
Center for Genomics and Systems Biology, New York University
Co-authored papers 3
Nir Hacohen
Broad Institute of MIT and Harvard
Co-authored papers 3
Mariella G Filbin
Co-authored papers 3
Pablo Tamayo
University of California San Diego
Co-authored papers 3
Jia-Ren Lin
Co-authored papers 3
Release 1.2