Author details

Full Name

David J Dix

Affiliation

ORCID

Career Start Year

1987

Papers

122

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
29146384	Identification of candidate reference chemicals for in vitro steroidogenesis assays.	Toxicology in Vitro	2018
29214797	High-throughput in Vitro Data To Inform Prioritization of Ambient Water Monitoring and Testing for Endocrine Active Chemicals.	Environmental Science & Technology	2018
27933809	Development and Validation of a Computational Model for Androgen Receptor Activity.	Chemical Research in Toxicology	2017
28934726	Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program.	Environmental Health Perspectives	2017
28520487	Chemical Risk Assessment: Traditional vs Public Health Perspectives.	American Journal of Public Health	2017
27589887	Identifying reference chemicals for thyroid bioactivity screening.	Reproductive Toxicology	2016
26972864	Spanning regulatory silos in the U.S. EPA's Endocrine Disruptor Screening Program: Letter to the Editor re: Evans et al. "Should the scope of human mixture risk assessment span legislative and regulatory silos for chemicals?".	Science of the Total Environment	2016
27049553	Letter to the Editor: Response to "Second Scientific Statement on Endocrine-Disrupting Chemicals" by Gore et al.	Endocrine Reviews	2016
26473631	Using ToxCastâ¿¢ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.	Environ Health Perspect	2016
24960280	Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.	Environ Sci Technol	2014
25012808	Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.	Sci Rep	2014
24837663	Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.	Nat Biotechnol	2014
23024176	In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.	Toxicol Sci	2013
23682706	Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.	Chem Res Toxicol	2013
23052129	Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.	Environ Health Perspect	2013
23592958	A computational model predicting disruption of blood vessel development.	PLoS Comput Biol	2013
23338806	Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.	ALTEX	2013
23611293	Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.	Chem Res Toxicol	2013
21948869	Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.	Toxicological Sciences	2012
22875311	Advancing the next generation of health risk assessment.	Environmental Health Perspectives	2012
22519603	Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.	Chem Res Toxicol	2012
22982683	Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.	Toxicol Sci	2012
22239076	Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program.	Systems Biology in Reproductive Medicine	2012
22182468	Zebrafish developmental screening of the ToxCastâ¿¢ Phase I chemical library.	Reprod Toxicol	2012
21543282	Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.	Environ Health Perspect	2011
21130863	Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring.	Reproductive Toxicology	2011
21384849	Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.	Chemical Research in Toxicology	2011
21339822	Using nuclear receptor activity to stratify hepatocarcinogens.	PLoS One	2011
21251949	Activity profiles of 309 ToxCastâ¿¢ chemicals evaluated across 292 biochemical targets.	Toxicology	2011
21925528	Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics.	Toxicology and Applied Pharmacology	2011
21565999	Predictive model of rat reproductive toxicity from ToxCast high throughput screening.	Biol Reprod	2011
21666745	Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.	PLoS One	2011
21873373	Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.	Toxicol Sci	2011
21788197	Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential.	Environmental Health Perspectives	2011
21788198	Environmental impact on vascular development predicted by high-throughput screening.	Environ Health Perspect	2011
20639261	Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.	Toxicol Sci	2010
20826373	Endocrine profiling and prioritization of environmental chemicals using ToxCast data.	Environ Health Perspect	2010
20676074	The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.	Nat Biotechnol	2010
20574906	Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.	J Toxicol Environ Health B Crit Rev	2010
20574897	Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.	Journal of Toxicology and Environmental Health - Part B: Critical Reviews	2010
20227205	Effect of season on fresh and cryopreserved stallion semen.	Animal Reproduction Science	2010
20602530	Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.	Environ Sci Technol	2010
20368123	In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.	Environ Health Perspect	2010
20143881	Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.	Chem Res Toxicol	2010
19938956	Inhibition of rat and human steroidogenesis by triazole antifungals.	Systems Biology in Reproductive Medicine	2009
19409404	Toxicogenomic effects common to triazole antifungals and conserved between rats and humans.	Toxicology and Applied Pharmacology	2009
19639652	Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice.	Birth Defects Research Part A - Clinical and Molecular Teratology	2009
19591892	Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals.	Regulatory Toxicology and Pharmacology	2009
19446433	Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB.	Reproductive Toxicology	2009
19363143	Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database.	Toxicological Sciences	2009