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| 27335255 | Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK. | Bioorg Med Chem Lett | 2016 |
| 27592744 | Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy. | Bioorg Med Chem Lett | 2016 |
| 27437075 | Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent. | ACS Med Chem Lett | 2016 |
| 24867403 | The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents. | J Med Chem | 2015 |
| 25763473 | The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents. | J Med Chem | 2015 |
| 25723005 | The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent. | J Med Chem | 2015 |
| 25043312 | Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. | Bioorg Med Chem | 2014 |
| 25043604 | Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. | Cancer Cell | 2014 |
| 23433440 | In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics. | J Chemother | 2013 |
| 23829549 | The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. | J Med Chem | 2013 |
| 23663739 | Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy Lafora disease. | Cell Metab | 2013 |
| 22948878 | Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor. | Antimicrob Agents Chemother | 2012 |
| 19521826 | Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. | Methods Mol Biol | 2009 |
| 19682901 | Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI). | Bioorg Med Chem Lett | 2009 |
| 19682900 | 2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI. | Bioorg Med Chem Lett | 2009 |
| 17092916 | Screening for ligands using a generic and high-throughput light-scattering-based assay. | J Biomol Screen | 2006 |
| 12421828 | Cytoskeleton interactions involved in the assembly and function of glycoprotein-80 adhesion complexes in dictyostelium. | J Biol Chem | 2003 |
| 12692127 | Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes. | J Biol Chem | 2003 |
| 11278598 | Involvement of a triton-insoluble floating fraction in Dictyostelium cell-cell adhesion. | J Biol Chem | 2001 |
| 11071787 | The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development. | Dev Biol | 2000 |
| 10908574 | The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. | J Cell Biol | 2000 |
| 9712887 | Yeast transcript elongation factor (TFIIS), structure and function. I: NMR structural analysis of the minimal transcriptionally active region. | J Biol Chem | 1998 |
| 9712888 | Yeast transcript elongation factor (TFIIS), structure and function. II: RNA polymerase binding, transcript cleavage, and read-through. | J Biol Chem | 1998 |
| 9169440 | Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS. | J Biol Chem | 1997 |
| 8855225 | Elongation factor TFIIS contains three structural domains: solution structure of domain II. | Proc Natl Acad Sci U S A | 1996 |
| 18629920 | Permeability of alginate microcapsules to secretory recombinant gene products. | Biotechnol Bioeng | 1996 |
| 8876173 | In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS. | Proc Natl Acad Sci U S A | 1996 |
| 8288647 | Purified yeast RNA polymerase II reads through intrinsic blocks to elongation in response to the yeast TFIIS analogue, P37. | J Biol Chem | 1994 |
| 18615439 | Growth of recombinant fibroblasts in alginate microcapsules. | Biotechnol Bioeng | 1994 |