Author details

Full Name

Can Zhang

Affiliation

ORCID

Career Start Year

2006

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37461700	In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimer's Disease Models.		2023
37986905	PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.		2023
37712902	Bioluminescence Imaging with Functional Amyloid Reservoirs in Alzheimer's Disease Models.		2023
37398461	HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates.	bioRxiv	2023
37461701	Degradation of amyloid beta species by multi-copper oxidases.		2023
35084109	Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease.	Alzheimers Dement	2022
35760872	Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation.	Nature Metabolism	2022
36213537	Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease.	Acta Pharmaceutica Sinica B	2022
35728383	Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.	Phytomedicine	2022
35919434	Epitope alteration by small molecules and applications in drug discovery.	Chemical Science	2022
35401099	Association of the Protein-Quality-Control Protein Ubiquilin-1 With Alzheimer's Disease Both and .	Frontiers in Neuroscience	2022
34160128	Plasma IL-12/IFN-Î³ axis predicts cognitive trajectories in cognitively unimpaired older adults.	Alzheimers Dement	2022
35333038	Rapid Biomarker Screening of Alzheimer's Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy.	ACS Nano	2022
34854884	Gut microbiota-driven brain AÎ² amyloidosis in mice requires microglia.	Journal of Experimental Medicine	2022
35248531	Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models.	Journal of Biological Chemistry	2022
34812607	Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I.	ACS Chemical Neuroscience	2021
33860595	Molecular imaging of NAD -dependent deacetylase SIRT1 in the brain.	Alzheimer's and Dementia	2021
33822840	An APP ectodomain mutation outside of the AÎ² domain promotes AÎ² production in vitro and deposition in vivo.	Journal of Experimental Medicine	2021
33651103	Preclinical validation of a potent Î³-secretase modulator for Alzheimer's disease prevention.	J Exp Med	2021
32889847	Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells.	Anesthesia and Analgesia	2021
33418063	Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome.	Bioorganic and Medicinal Chemistry Letters	2021
34385058	Gestational exposure to PM leads to cognitive dysfunction in mice offspring via promoting HMGB1-NLRP3 axis mediated hippocampal inflammation.	Ecotoxicology and Environmental Safety	2021
34652135	Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography.	Journal of Medicinal Chemistry	2021
32663728	B-vitamin supplementation ameliorates anxiety- and depression-like behavior induced by gestational urban PM exposure through suppressing neuroinflammation in mice offspring.	Environmental Pollution	2020
31995180	Negative evidence for a role of APH1B T27I variant in Alzheimer's disease.	Human Molecular Genetics	2020
32936886	Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates.	Journal of Experimental Medicine	2020
32597805	Upregulation of Alzheimer's Disease Amyloid-Î² Protein Precursor in Astrocytes Both in vitro and in vivo.	J Alzheimers Dis	2020
32792510	Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo.	Nature Communications	2020
31546205	Gestational B-vitamin supplementation alleviates PM-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring.	Ecotoxicology and Environmental Safety	2019
31640731	The high-affinity IgG receptor FcÎ³RI modulates peripheral nerve injury-induced neuropathic pain in rats.	Molecular Brain	2019
31640096	A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-Î² Protein by Modulating AÎ²PP Processing and Autophagy.	Journal of Alzheimer's Disease	2019
31609093	Significant Upregulation of Alzheimer's Î²-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides.	Angewandte Chemie - International Edition	2019
31156396	Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway.	Frontiers in Cellular Neuroscience	2019
30666183	Gestational Exposure to Particulate Matter 2.5 (PM) Leads to Spatial Memory Dysfunction and Neurodevelopmental Impairment in Hippocampus of Mice Offspring.	Frontiers in Neuroscience	2018
30190379	Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.	Science	2018
29348604	Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid Î²-Protein by Promoting Microglial Phagocytosis.	Sci Rep	2018
29408929	Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome.	PLoS ONE	2018
28919280	Soluble Gamma-secretase Modulators Attenuate Alzheimer's Î²-amyloid Pathology and Induce Conformational Changes in Presenilin 1.	eBioMedicine	2017
28989646	The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants.	Chemical Science	2017
28720893	Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin.	Scientific Reports	2017
28416568	Pharmacological and Toxicological Properties of the Potent Oral <i>Î³</i>-Secretase Modulator BPN-15606.	J Pharmacol Exp Ther	2017
28371615	Mechanisms that synergistically regulate Î·-secretase processing of APP and AÎ·-Î± protein levels: relevance to pathogenesis and treatment of Alzheimer's disease.		2017
28371613	Developing effective therapeutics for Alzheimer's disease -- emerging mechanisms and actions in translational medicine.		2017
28874832	Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP/PS1 murine model of Alzheimer's disease.	Scientific Reports	2017
27443609	Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.	Scientific Reports	2016
26199414	Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.	Proceedings of the National Academy of Sciences of the United States of America	2015
25910068	Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.	Biochemistry	2015
26348101	Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.	Biochemistry	2015
24599465	Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of Î²-amyloid by cells other than excitatory neurons.	Journal of Neuroscience	2014
25307057	A three-dimensional human neural cell culture model of Alzheimer's disease.	Nature	2014