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Author Details

Peter C Searson
Institute for NanoBioTechnology, Johns Hopkins University
1992
144
40
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37573260A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood-brain barrier endothelium.J Comput Aided Mol Des2023
37644124The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation.Nat Nanotechnol2023
36156464Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model.Adv Sci (Weinh)2022
35773691Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington's disease.Fluids Barriers CNS2022
35476363Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization.FASEB J2022
35349483IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function.JCI Insight2022
35398340Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity.Neurobiol Dis2022
35551622Effects of acute and chronic oxidative stress on the blood-brain barrier in 2D and 3D in vitro models.Fluids Barriers CNS2022
36312050Engineering the human blood-brain barrier at the capillary scale using a double-templating technique.Adv Funct Mater2022
36333694Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels.Fluids Barriers CNS2022
34147718Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo.Biomaterials2021
35036773Atomistic Model of Solute Transport across the Blood-Brain Barrier.ACS Omega2021
34876171Next-generation in vitro blood-brain barrier models: benchmarking and improving model accuracy.Fluids Barriers CNS2021
31394959Modeling hyperosmotic blood-brain barrier opening within human tissue-engineered in vitro brain microvessels.J Cereb Blood Flow Metab2020
31751635Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex.J Control Release2020
33263987A Capacitive Sweat Rate Sensor for Continuous and Real-Time Monitoring of Sweat Loss.ACS Sens2020
32665356A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer.Cancer Res2020
32673611Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis.Microvasc Res2020
32787285Long-Term Cryopreservation Preserves Blood-Brain Barrier Phenotype of iPSC-Derived Brain Microvascular Endothelial Cells and Three-Dimensional Microvessels.Mol Pharm2020
32474121A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action.J Control Release2020
32181827Assessment of Patient Ambulation Profiles to Predict Hospital Readmission, Discharge Location, and Length of Stay in a Cardiac Surgery Progressive Care Unit.JAMA Netw Open2020
32382047The Dynamic Response of Sweat Chloride to Changes in Exercise Load Measured by a Wearable Sweat Sensor.Sci Rep2020
32258431Out-of-clinic measurement of sweat chloride using a wearable sensor during low-intensity exercise.NPJ Digit Med2020
30391800Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior.Biomaterials2019
31784588Two Distinct Types of Sweat Profile in Healthy Subjects While Exercising at Constant Power Output Measured by a Wearable Sweat Sensor.Sci Rep2019
33405827Chemotherapeutic Drug Delivery and Quantitative Analysis of Proliferation, Apoptosis, and Migration in a Tissue-Engineered Three-Dimensional Microvessel Model of the Tumor Microenvironment.ACS Biomater Sci Eng2019
31562392Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells.Sci Rep2019
31303172The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.Fluids Barriers CNS2019
31612183Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.Nanoscale2019
31208241Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels.J Cereb Blood Flow Metab2019
31167667Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D.Fluids Barriers CNS2019
31021744Wearable Devices for Precision Medicine and Health State Monitoring.IEEE Trans Biomed Eng2019
30992465An experimentally validated approach to calculate the blood-brain barrier permeability of small molecules.Sci Rep2019
29122661Leakage kinetics of the liposomal chemotherapeutic agent Doxil: The role of dissolution, protonation, and passive transport, and implications for mechanism of action.J Control Release2018
30139940Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality.Sci Rep2018
30514389Benchmarking in vitro tissue-engineered blood-brain barrier models.Fluids Barriers CNS2018
30415016Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks.J Control Release2018
30507558Distinguishing positions and movements in bed from load cell signals.Physiol Meas2018
29701946Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor.ACS Appl Mater Interfaces2018
29580829Sweat test for cystic fibrosis: Wearable sweat sensor vs. standard laboratory test.J Cyst Fibros2018
29413419Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways.Trends Cancer2018
29463314Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation.Fluids Barriers CNS2018
27313077Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges.Adv Drug Deliv Rev2017
28254372Tumor accumulation of liposomal doxorubicin in three murine models: Optimizing delivery efficiency.Nanomedicine2017
28457227NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.Fluids Barriers CNS2017
28164421Tissue-engineered 3D microvessel and capillary network models for the study of vascular phenomena.Microcirculation2017
28358586Utility of microfluidic devices to study the platelet-endothelium interface.Platelets2017
28478327High throughput differential identification of TMPRSS2-ERG fusion genes in prostate cancer patient urine.Biomaterials2017
28150206Quantitative Evaluation of the Enhanced Permeability and Retention (EPR) Effect.Methods Mol Biol2017
28345713Real-time quantification of endothelial response to shear stress and vascular modulators.Integr Biol (Camb)2017
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Collaborators

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Co-authored papers 7
Duke University, Johns Hopkins University
Co-authored papers 5
c Center for Devices and Radiological Health
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University of California San Diego
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Co-authored papers 3
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Co-authored papers 2
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Co-authored papers 2
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University of California los angeles
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Co-authored papers 1
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Johns Hopkins University School of Medicine
Co-authored papers 1
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Co-authored papers 1
Co-authored papers 1
Tulane University School of Medicine
Co-authored papers 1
The Johns Hopkins University
Co-authored papers 1
Howard Hughes Medical Institute
Co-authored papers 1
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Department of Medicine Johns Hopkins Medicine. Baltimore MD 21205USA.
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
University of Washington
Co-authored papers 1