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Author Details

Tesa M Severson
Oncode Institute, The Netherlands Cancer Institute
2002
44
26
PMIDPaper TitleJournal TitlePublished Year
36865297Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients.medRxiv2023
37271632Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor-driven Programs.Eur Urol2023
37070193PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.Nucleic Acids Res2023
36107780Double-strand break toxicity is chromatin context independent.Nucleic Acids Res2022
35509021Androgen receptor reprogramming demarcates prognostic, context-dependent gene sets in primary and metastatic prostate cancer.Clin Epigenetics2022
35754340Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence.Cancer Discov2022
36450752Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.Nat Commun2022
33452241The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.Nat Commun2021
33576154Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases.Mol Oncol2021
34737261Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.Nat Commun2021
34272384Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.Nat Commun2021
32484599The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer.Mol Oncol2020
31974375Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.Nat Commun2020
32690948Prostate cancer reactivates developmental epigenomic programs during metastatic progression.Nat Genet2020
30514804Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-<i>trans</i> retinoic acid in acute myeloid leukemia across subtypes.Haematologica2019
31797935CD4<sup>+</sup> T cell help creates memory CD8<sup>+</sup> T cells with innate and help-independent recall capacities.Nat Commun2019
31735626Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.Cancer Cell2019
31036541EZH2 Is Overexpressed in <i>BRCA1</i>-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy.Clin Cancer Res2019
29396493Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer.Nat Commun2018
30041599Mitotic count can predict tamoxifen benefit in postmenopausal breast cancer patients while Ki67 score cannot.BMC Cancer2018
30524905Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, <i>BRCA1</i>-like status, tumor-infiltrating immune cells and survival.Oncoimmunology2018
29719599Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects <i>in vitro</i> and poor outcome in patients with advanced head and neck squamous cell carcinoma.Oncotarget2018
29760405ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors.Oncogene2018
28062545A review of estrogen receptor/androgen receptor genomics in male breast cancer.Endocr Relat Cancer2017
28948212DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial.NPJ Breast Cancer2017
28851423The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.Breast Cancer Res2017
26729235Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.Sci Rep2016
27197147Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas.Cancer Res2016
27129152Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.Oncotarget2016
26004083BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.Mol Oncol2015
25825120Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.Mol Oncol2015
24467828PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients.Breast Cancer Res2014
24447434Phosphorylated p-70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment.Breast Cancer Res2014
22249354Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.Pharmacogenomics J2013
23736997CYP2C19 2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment.Breast Cancer Res Treat2013
21796119Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.Nature2011
20081860Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.Nat Genet2010
21129721Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome.Am J Hum Genet2010
20696054Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors.Genome Biol2010
20884631Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.Cancer Res2010
19812674Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.Nature2009
18493019A novel DNA sequence database for analyzing human demographic history.Genome Res2008
15483323Evidence for archaic Asian ancestry on the human X chromosome.Mol Biol Evol2005
12454039Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library.Invest Ophthalmol Vis Sci2002
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Collaborators

Oncode Institute, The Netherlands Cancer Institute
Co-authored papers 17
University Medical Centre Mannheim, University of Heidelberg
Co-authored papers 14
The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital
Co-authored papers 9
University of British Columbia
Co-authored papers 7
Co-authored papers 7
Simon Fraser University
Co-authored papers 7
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 6
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization
Co-authored papers 6
Dana-Farber Cancer Institute
Co-authored papers 6
University Medical Center Utrecht
Co-authored papers 5
Canada British Columbia Cancer Research Centre, University of British Columbia
Co-authored papers 5
University of British Columbia
Co-authored papers 5
University of British Columbia
Co-authored papers 4
Dana-Farber Cancer Institute
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
BC Cancer Research Institute
Co-authored papers 4
The Netherlands Cancer Institute
Co-authored papers 4
Canada British Columbia Cancer Research Centre, University of British Columbia
Co-authored papers 3
Co-authored papers 3
David Geffen School of Medicine, University of California los angeles
Co-authored papers 3
UCSF Medical Center-Mount Zion
Co-authored papers 3
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Washington University
Co-authored papers 3
Washington University
Co-authored papers 3
University of California San Francisco
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Princess Margaret Cancer Center, University Health Network, University of Toronto
Co-authored papers 2
University of California los angeles
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Oncode Institute, Netherlands Cancer Institute
Co-authored papers 2