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Author Details

Tak W Mak
Princess Margaret Cancer Centre, University Health Network
1970
1066
181
PMIDPaper TitleJournal TitlePublished Year
35302667Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity.Hepatology2023
37843275Chemical carcinogens: implications for cancer treatment.J Clin Invest2023
37729199HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.Proc Natl Acad Sci U S A2023
37640929Tumor-specific cholinergic CD4<sup>+</sup> T lymphocytes guide immunosurveillance of hepatocellular carcinoma.Nat Cancer2023
37493438Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.J Immunol2023
36652477Distinct and opposite effects of leukemogenic <i>Idh</i> and <i>Tet2</i> mutations in hematopoietic stem and progenitor cells.Proc Natl Acad Sci U S A2023
36736318IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.Cancer Cell2023
36762786Nucleolar stress: Molecular mechanisms and related human diseases.Cancer Sci2023
36528755Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis.Cell Death Differ2023
35023164Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.EMBO J2022
35705312Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab.J Immunother Cancer2022
35581387Immune response in COVID-19: what is next?Cell Death Differ2022
35641782DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis.Cell Death Differ2022
35532794TREM-2 mediates dendritic cell-induced NO to suppress Th17 activation and ameliorate chronic kidney diseases.J Mol Med (Berl)2022
35817786Reply to: Questioning whether the IgM Fc receptor (FcμR) is expressed by innate immune cells.Nat Commun2022
35936010TRAPS mutations in <i>Tnfrsf1a</i> decrease the responsiveness to TNFα <i>via</i> reduced cell surface expression of TNFR1.Front Immunol2022
36370712The transcription factor IRF2 drives interferon-mediated CD8<sup>+</sup> T cell exhaustion to restrict anti-tumor immunity.Immunity2022
36070391The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER<sup>+</sup> breast cancer with mitotic aberrations.Sci Adv2022
35985343De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.Cancer Cell2022
36054428N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ.Genes Cells2022
35914158CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma.Proc Natl Acad Sci U S A2022
34995099Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.Sci Immunol2022
33444287Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.J Clin Invest2021
33686237Beyond immune checkpoint blockade: emerging immunological strategies.Nat Rev Drug Discov2021
33826883Influence of the microenvironment on modulation of the host response by typhoid toxin.Cell Rep2021
33649568Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4<sup>+</sup> T cells.Nat Biotechnol2021
33561544Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.Mol Metab2021
33664482GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.Cell Death Differ2021
33931442Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion.Sci Adv2021
33633277Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages.Sci Rep2021
33526692IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions.Proc Natl Acad Sci U S A2021
33772013Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection.Nat Commun2021
34663907Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19.Cell Death Differ2021
34301789Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.Cancer Discov2021
34015029Correction: The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila.PLoS One2021
34059798The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.Cell Death Differ2021
34289205Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.Cancer Sci2021
34142411TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands.Genes Cells2021
33254233IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis.Blood2021
33335286From the T-cell receptor to cancer therapy: an interview with Tak W. Mak.Cell Death Differ2021
33159406The role of Hippo-YAP signaling in squamous cell carcinomas.Cancer Sci2021
33360716Illuminating the cross-talk between tumor metabolism and immunity in IDH-mutated cancers.Curr Opin Biotechnol2021
32314731Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma.Elife2020
34124690Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs.Nat Cancer2020
32060096ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).J Biol Chem2020
31728055Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML.Leukemia2020
31710126Beyond neurotransmission: acetylcholine in immunity and inflammation.J Intern Med2020
32103528Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.FASEB J2020
32094913Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas.Nat Genet2020
32062352Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis.EBioMedicine2020
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Collaborators

Andrew Wakeham
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
Co-authored papers 116
Andrew J Elia
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 65
Thorsten Berger
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 51
David W Cescon
Princess Margaret Cancer Centre
Co-authored papers 27
Razqallah Hakem
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 26
Chiara Gorrini
Division of Clinical Studies, The Institute of Cancer Research
Co-authored papers 20
Jacqueline M Mason
Campbell Family Institute for Breast Cancer Research, University Health Network
Co-authored papers 18
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 14
Raymond H Kim
Cardiac Genome Clinic, The Hospital for Sick Children
Co-authored papers 13
Aleksandra A Pandyra
Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf
Co-authored papers 12
Anne Hakem
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
Rama Khokha
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 10
Christopher J Paige
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
Donald E Awrey
The Campbell Family Institute for Breast Cancer Research, College Street
Co-authored papers 9
Susan J Done
University Health Network
Co-authored papers 8
Heiko Blaser
Princess Margaret Cancer Centre
Co-authored papers 8
Paul D Waterhouse
Princess Margaret Cancer Centre/University Health Network
Co-authored papers 7
Benjamin Haibe-Kains
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 7
Hossein Aleyasin
Co-authored papers 6
Mathieu Lupien
Princess Margaret Cancer Research Centre
Co-authored papers 6
Evan F Lind
Oregon Health & Science University
Co-authored papers 6
James R Woodgett
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 6
Eldad Zacksenhaus
University of Toronto
Co-authored papers 6
Dan Chi-Chia Lin
College of Life Science, Fujian Normal University
Co-authored papers 6
Yi Zheng
Children's Hospital Research Foundation
Co-authored papers 6
Brian Tomlinson
Co-authored papers 5
Andrea Jurisicova
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 5
Gang Lu
Co-authored papers 5
Garry P Nolan
Stanford University School of Medicine
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Hal K Berman
Princess Margaret Cancer Centre, University Health Network
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Release 1.2