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Author Details

Jason Moffat
University of Toronto
1997
167
57
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36627300Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.Nat Commun2023
37891180N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.Nat Commun2023
37202533Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.Commun Biol2023
37201508Reproducibility metrics for context-specific CRISPR screens.Cell Syst2023
36597481Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors.Heliyon2023
34709608A Method to Map Gene Essentiality of Human Pluripotent Stem Cells by Genome-Scale CRISPR Screens with Inducible Cas9.Methods Mol Biol2022
37214176High-content CRISPR screening.Nat Rev Methods Primers2022
36473869Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.Nat Commun2022
36482254A cohesin traffic pattern genetically linked to gene regulation.Nat Struct Mol Biol2022
36002506Author Correction: Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.Nat Chem Biol2022
35874663Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors.Front Immunol2022
35970996Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.Nat Chem Biol2022
36178522The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers.Acta Neuropathol2022
36368321Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.Cancer Cell2022
36270234Context-dependent regulation of ferroptosis sensitivity.Cell Chem Biol2022
36170831Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma.Cell Rep2022
36382110Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies.Neurooncol Adv2022
35953550Identifying cell receptors for the nanoparticle protein corona using genome screens.Nat Chem Biol2022
35914530Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis.Mol Cell2022
35017149CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment.J Immunother Cancer2022
34911733Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer.Cancer Discov2022
35087171Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting.Nat Biomed Eng2022
33417860Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.Cell2021
34765972Identification of five important genes to predict glioblastoma subtypes.Neurooncol Adv2021
34819670FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.Nature2021
34462321Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene <i>STAG2</i>.Life Sci Alliance2021
34508259Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline.Nat Protoc2021
34018332A method for benchmarking genetic screens reveals a predominant mitochondrial bias.Mol Syst Biol2021
33962950NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4.Sci Adv2021
34083438LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions.Proc Natl Acad Sci U S A2021
32464096The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma.Cell Stem Cell2020
31695152A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells.Oncogene2020
32107292Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.J Cell Sci2020
31881079IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.J Cell Biol2020
33177493Digital microfluidic isolation of single cells for -Omics.Nat Commun2020
32968282Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.Nature2020
32572160Functional genomics identifies new synergistic therapies for retinoblastoma.Oncogene2020
32694731Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.Nat Metab2020
32249828Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform.Nat Biotechnol2020
30523157Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.J Biol Chem2019
31464370CRISPR screens are feasible in TP53 wild-type cells.Mol Syst Biol2019
31548591High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.Nat Biomed Eng2019
31545321Pooled CRISPR-Based Genetic Screens in Mammalian Cells.J Vis Exp2019
31452509Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.Elife2019
31566424Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.Am J Physiol Renal Physiol2019
30713027Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.Structure2019
30894493Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.Proc Natl Acad Sci U S A2019
31115870Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.J Neurooncol2019
30974317Genetic interaction networks in cancer cells.Curr Opin Genet Dev2019
30763569Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.J Mol Biol2019
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Collaborators

Kevin R Brown
College Street, University of Toronto
Co-authored papers 41
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 23
Brenda J Andrews
University of Toronto
Co-authored papers 21
Charles Boone
University of Toronto
Co-authored papers 15
Sheila K Singh
McMaster University
Co-authored papers 15
Traver Hart
University of Texas MD Anderson Cancer Center
Co-authored papers 15
Chitra Venugopal
McMaster Stem Cell and Cancer Research Institute
Co-authored papers 13
Amy Hin Yan Tong
University of Toronto
Co-authored papers 13
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 11
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 10
Chirayu Chokshi
McMaster University
Co-authored papers 10
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 9
Alessandro Datti
University of Perugia
Co-authored papers 9
Chad L Myers
University of Minnesota - Twin Cities
Co-authored papers 9
Benjamin J Blencowe
University of Toronto
Co-authored papers 9
Hong Han
Hangzhou City University
Co-authored papers 8
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 8
Michael Costanzo
Co-authored papers 8
Rose Hurren
Princess Margaret Cancer Centre
Co-authored papers 7
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 7
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 6
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 6
Nazanin Tatari
McMaster University
Co-authored papers 6
Marcela Gronda
Princess Margaret Cancer Centre
Co-authored papers 6
Zachary Steinhart
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 6
Tony Pawson
Co-authored papers 5
Michael F Moran
Hospital for Sick Children, University of Toronto
Co-authored papers 5
Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 5
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
John Provias
McMaster University
Co-authored papers 4
Release 1.2