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Author Details

Hugues de Th??
Universite Paris Cite, Inserm, CNRS, Institut de Recherche Saint-Louis
1983
283
81
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36736290Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia.Cell Stem Cell2023
37655965Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function.Cancer Discov2023
36948605Ypel5 regulates liver development and function in zebrafish.J Mol Cell Biol2023
37382966The PML hub: An emerging actor of leukemia therapies.J Exp Med2023
37137914Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival.Blood Cancer J2023
36624101Author Correction: Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells.Nat Commun2023
34134475An exciting RXRA mutant revives interest in retinoids for acute myeloid leukemia.Haematologica2022
35474100Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia.Leukemia2022
36074531In APL, noncoding mutations and SNP converge on WT1.Blood2022
36175410Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells.Nat Commun2022
36205309Zbtb14 regulates monocyte and macrophage development through inhibiting <i>pu.1</i> expression in zebrafish.Elife2022
35246604Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication.Leukemia2022
35269436Sumoylation in Physiology, Pathology and Therapy.Cells2022
32709934Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway.Cell Death Differ2021
33654209Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.Leukemia2021
33651885Retinoids in hematology: a timely revival?Blood2021
33567810Loss of interleukin-10 activates innate immunity to eradicate adult T-cell leukemia-initiating cells.Haematologica2021
34131282A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA.Leukemia2021
34351909Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.PLoS Genet2021
34301789Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.Cancer Discov2021
34003103[Arsenic: The gold standard for acute promyelocytic leukaemia with FLT3-ITD mutation].Med Sci (Paris)2021
34230915PML/RARA destabilization by hyperthermia: a new model for oncogenic fusion protein degradation?Blood Cancer Discov2021
34047175A Pin1/PML/P53 axis activated by retinoic acid in <i>NPM-1c</i> acute myeloid leukemia.Haematologica2021
33075130JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.J Exp Med2021
31123027Interferon regulatory factor 2 binding protein 2b regulates neutrophil <i>versus</i> macrophage fate during zebrafish definitive myelopoiesis.Haematologica2020
31968250Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow.Cell Rep2020
32323922Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress.EMBO Mol Med2020
32295268Classic and Variants APLs, as Viewed from a Therapy Response.Cancers (Basel)2020
32199462Arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) as a maintenance therapy for adult T cell leukemia/lymphoma.Retrovirology2020
30674471<i>FLT3</i>-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.Blood2019
30244973PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers.Cell Metab2019
31431473A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells.Life Sci Alliance2019
31374198Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.Cell Stem Cell2019
31311814Primitive macrophages are dispensable for HSPC mobilization and definitive hematopoiesis.Blood2019
30824836TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy.Cell Death Differ2019
29192213Differentiation therapy revisited.Nat Rev Cancer2018
30266821Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.Blood Adv2018
30266814Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation.Cancer Discov2018
29728567Publisher Correction: RING tetramerization is required for nuclear body biogenesis and PML sumoylation.Nat Commun2018
29723661PML nuclear bodies: from architecture to function.Curr Opin Cell Biol2018
29634367RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPα axis.FASEB J2018
29467492The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia.Oncogene2018
29599493RING tetramerization is required for nuclear body biogenesis and PML sumoylation.Nat Commun2018
29507418Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner.Oncogene2018
29795382Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.Nat Commun2018
29157919PML nuclear bodies, membrane-less domains acting as ROS sensors?Semin Cell Dev Biol2018
28074026Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection.mBio2017
28285006GATA5 SUMOylation is indispensable for zebrafish cardiac development.Biochim Biophys Acta Gen Subj2017
29136503Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure.Cancer Cell2017
28931625PML is a ROS sensor activating p53 upon oxidative stress.J Exp Med2017
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Collaborators

Zhu Chen
Yong Loo Lin School of Medicine, National University of Singapore
Co-authored papers 29
Hao Yuan
Co-authored papers 16
Hsin-Chieh Wu
Chaoyang University of Technology
Co-authored papers 8
Herv?? Dombret
Institut de Recherche Saint-Louis, Universite de Paris
Co-authored papers 8
Lionel Ad??s
Assistance Publique des Hopitaux de Paris (AP-HP)
Co-authored papers 7
Emmanuel Raffoux
Universite Paris Diderot
Co-authored papers 6
Rodrigo Arriagada
Co-authored papers 4
Jean Soulier
University of Paris
Co-authored papers 4
Emmanuelle Clappier
Saint-Louis Hospital
Co-authored papers 4
Lajos Pusztai
Co-authored papers 4
Claude Preudhomme
Lille University Hospital, INSERM UMR-S7, CNRS UMR9020, Lille University.
Co-authored papers 3
Christos Sotiriou
Co-authored papers 3
Alexandra Durr
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 3
Alexis Brice
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 3
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Matthieu Duchmann
Assistance Publique-Hopitaux de Paris, Universite de Paris
Co-authored papers 2
Gabriel N Hortobagyi
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Giovanni Stevanin
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 2
Raphael Itzykson
Universite Paris Cite, INSERM, CNRS
Co-authored papers 2
Louis M Staudt
National Cancer Institute, National Institutes of Health
Co-authored papers 2
Hendrik G Stunnenberg
Co-authored papers 2
William F Symmans
Co-authored papers 2
Daniel Birnbaum
Co-authored papers 2
Ming Zhan
Ningbo First Hospital, Zhejiang University
Co-authored papers 2
Bas van Steensel
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 1
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 1
Nina Fenouille
Universite Paris Cite, INSERM, CNRS
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Bryann Pardieu
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Release 1.2