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Author Details

Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
1980
369
78
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36369049Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes.J Surg Res2023
37898401Proteases influence colony aggregation behavior in Vibrio cholerae.J Biol Chem2023
37504081A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19.Biosensors (Basel)2023
37354015Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.Protein Sci2023
37254128Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.Mol Neurodegener2023
36948708Multiplex substrate profiling by mass spectrometry for proteases.Methods Enzymol2023
37184546Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.Biochemistry2023
37404982Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.Ann Transl Med2023
37131250Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.Mol Neurodegener2023
37330289The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).J Mol Biol2023
36859773High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions.MAbs2023
34800659Design of a population-based longitudinal cohort study of SARS-CoV-2 incidence and prevalence among adults in the San Francisco Bay Area.Ann Epidemiol2022
35741154Translation of a Protease Turnover Assay for Clinical Discrimination of Mucinous Pancreatic Cysts.Diagnostics (Basel)2022
35364007Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.Cell Chem Biol2022
36075902Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.Nat Commun2022
36099883A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.Cancer Cell2022
35960688Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M<sup>pro</sup> and Papain-like Protease PL<sup>pro</sup> of SARS-CoV-2.J Chem Inf Model2022
35279023Incidence and Prevalence of Coronavirus Disease 2019 Within a Healthcare Worker Cohort During the First Year of the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic.Clin Infect Dis2022
35018373Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2.bioRxiv2022
33221341Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity.Biochim Biophys Acta Proteins Proteom2021
33765766Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer.ACS Chem Biol2021
34735239Mapping the catalytic conformations of an assembly-line polyketide synthase module.Science2021
34494023Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens.bioRxiv2021
34729407In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.ACS Cent Sci2021
34548480Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.Nat Commun2021
34812616Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.J Med Chem2021
34694776Immunotargeting of Nanocrystals by SpyCatcher Conjugation of Engineered Antibodies.ACS Nano2021
34635581A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.Proc Natl Acad Sci U S A2021
33970001Beginning at the End(s): A Latent End-Binding Network at the Host-Pathogen Interface.Biochemistry2021
34131661A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.bioRxiv2021
33983947Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes.PLoS One2021
34006103Re-emerging Aspartic Protease Targets: Examining <i>Cryptococcus neoformans</i> Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.J Med Chem2021
33974910Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.Cell2021
31714737End-Binding E3 Ubiquitin Ligases Enable Protease Signaling.ACS Chem Biol2021
31449183Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.Transplantation2020
33301681Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.J Am Chem Soc2020
32786753Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.J Am Chem Soc2020
32699850Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.bioRxiv2020
32813112An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.Mol Imaging Biol2020
32839241An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans.Genetics2020
32246002Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes.Sci Rep2020
32523574Combination of Antifungal Drugs and Protease Inhibitors Prevent <i>Candida albicans</i> Biofilm Formation and Disrupt Mature Biofilms.Front Microbiol2020
32175287Isoforms of Cathepsin B1 in Neurotropic Schistosomula of <i>Trichobilharzia regenti</i> Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin.Front Cell Infect Microbiol2020
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
30689221Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation.Clin Transplant2019
31694242Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.Antibodies (Basel)2019
31320752Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.Nat Chem Biol2019
31404541KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.Am J Pathol2019
31256057The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.Biol Chem2019
30849700Why recombinant antibodies - benefits and applications.Curr Opin Biotechnol2019
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Collaborators

Robert J Fletterick
University of California San Francisco
Co-authored papers 37
Anthony J O'Donoghue
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 35
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 31
Conor R Caffrey
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 15
Robert M Stroud
University of California San Francisco
Co-authored papers 13
Giselle M Knudsen
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 12
Markus-Frederik Bohn
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 12
Natalia Sevillano
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 12
Jennifer L Harris
Co-authored papers 12
E Sigal
Institute of Biochemistry & Cell Biology
Co-authored papers 10
Michael B Winter
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Sami Mahrus
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 9
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 8
Mohammed Sajid
Qassim University
Co-authored papers 8
Florencia La Greca
Department of Pharmaceutical Chemistry , University of California san francisco
Co-authored papers 7
Dianne DeCamp
Co-authored papers 7
Matthew Ravalin
Stanford University
Co-authored papers 7
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 7
Linda S Brinen
The Joint Center for Structural Genomics, Stanford University
Co-authored papers 7
Volker D??tsch
Institute for Biophysical Chemistry, Goethe-University
Co-authored papers 6
Ami S Bhatt
Stanford University
Co-authored papers 6
Jan Dvor??k
Czech University of Life Sciences
Co-authored papers 6
Cathal Mahon
Denali Therapeutics Inc.
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Jonathan E Gable
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Co-authored papers 5
Philip J Rosenthal
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Matthew P Jacobson
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