Author details

Full Name

Jeffrey G McDonald

Affiliation

ORCID

Career Start Year

2005

Papers

106

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37491347	Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice.	Nat Commun	2023
36208831	Cutaneous Hormone Production Is Distinct between Anatomical Sites and between Males and Females.		2023
36416142	Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling.	Circulation	2023
37578898	Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice.		2023
36711703	Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3.		2023
36891609	Myocardial steatosis impairs left ventricular diastolic-systolic coupling in healthy humans.	J Physiol	2023
36824874	LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in .		2023
37461519	An enteroendocrine-microbial axis in the large intestine controls host metabolism.		2023
36821369	25-Hydroxycholesterol exacerbates vascular leak during acute lung injury.	JCI Insight	2023
36758549	Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.		2023
36695568	A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.		2023
37248394	Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases.		2023
37224812	Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.		2023
34923175	Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats.	Cellular and Molecular Gastroenterology and Hepatology	2022
35461764	Association of demographic and health characteristics with circulating oxysterol concentrations.	J Clin Lipidol	2022
35585236	Intracellular lipid surveillance by small G protein geranylgeranylation.	Nature	2022
36357390	A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience.	Nat Commun	2022
35882862	Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.	Nat Commun	2022
35379782	Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone.	Translational Psychiatry	2022
35941179	Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.	Nat Commun	2022
35934691	Introducing the Lipidomics Minimal Reporting Checklist.	Nat Metab	2022
36261024	Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization.	Cell Reports	2022
35857506	ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells.	Sci Adv	2022
36315147	Association of Vaginal Progesterone Treatment With Prevention of Recurrent Preterm Birth.	JAMA network open	2022
35533983	Transcriptional Integration of Distinct Microbial and Nutritional Signals by the Small Intestinal Epithelium.	Cell Mol Gastroenterol Hepatol	2022
35467977	FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids.	Proceedings of the National Academy of Sciences of the United States of America	2022
36505796	Repeated trans-arterial treatments of LDL-DHA nanoparticles induce multiple pathways of tumor cell death in hepatocellular carcinoma bearing rats.		2022
34992143	Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol.	Proceedings of the National Academy of Sciences of the United States of America	2022
34750386	MMAB promotes negative feedback control of cholesterol homeostasis.	Nature Communications	2021
34145255	Measurement of lipogenic flux by deuterium resolved mass spectrometry.	Nature Communications	2021
33989739	Decreased caveolae in AGPAT2 lacking adipocytes is independent of changes in cholesterol or sphingolipid levels: A whole cell and plasma membrane lipidomic analysis of adipogenesis.		2021
33242579	Assessing the safety of transarterial locoregional delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat liver.	European Journal of Pharmaceutics and Biopharmaceutics	2021
33408073	Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps.	Cancer Prev Res (Phila)	2021
34521750	Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis.	Proceedings of the National Academy of Sciences of the United States of America	2021
34782454	Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.	Proceedings of the National Academy of Sciences of the United States of America	2021
32617517	Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.	Nat Metab	2020
32417438	An implanted port-catheter system for repeated hepatic arterial infusion of low-density lipoprotein-docosahexaenoic acid nanoparticles in normal rats: A safety study.	Toxicology and Applied Pharmacology	2020
32362324	Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.	Immunity	2020
32343675	Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation.	JCI Insight	2020
32163279	A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins.	Journal of the American Chemical Society	2020
32284563	Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.	Nature Microbiology	2020
33310904	Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease.	Proceedings of the National Academy of Sciences of the United States of America	2020
33031742	Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens.	Cell	2020
32808593	Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress.	Elife	2020
32690708	Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine.	Proceedings of the National Academy of Sciences of the United States of America	2020
32913007	GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain.	Journal of Pharmacology and Experimental Therapeutics	2020
33070362	Decreased 11Î²-hydroxysteroid dehydrogenase 1 in lungs of steroid receptor coactivator (Src)-1/-2 double-deficient fetal mice is caused by impaired glucocorticoid and cytokine signaling.	FASEB Journal	2020
32792680	Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations.	Sci Rep	2020
31422916	Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes.	Developmental Cell	2019
31588013	Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass.	Cell Metab	2019