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Author Details

Marc C Deller
Incyte Corporation
2000
54
21
PMIDPaper TitleJournal TitlePublished Year
36356320Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.J Med Chem2022
29762030Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.J Am Chem Soc2018
28573591Validation of Protein-Ligand Crystal Structure Models: Small Molecule and Peptide Ligands.Methods Mol Biol2017
28257189The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase.ACS Chem Biol2017
28225819Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.PLoS Pathog2017
26841758Protein stability: a crystallographer's perspective.Acta Crystallogr F Struct Biol Commun2016
27067056Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.Immunity2016
25665575Models of protein-ligand crystal structures: trust, but verify.J Comput Aided Mol Des2015
26457433Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.Acta Crystallogr D Biol Crystallogr2015
25826626Crystal structure of a two-subunit TrkA octameric gating ring assembly.PLoS One2015
25825768Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.Proc Natl Acad Sci U S A2015
24637746Approaches to automated protein crystal harvesting.Acta Crystallogr F Struct Biol Commun2014
25197798Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin.PLoS One2014
23708606Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.Nat Struct Mol Biol2013
24179159Crystal structure of a soluble cleaved HIV-1 envelope trimer.Science2013
22411095Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.Proteins2012
22973046Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33.J Virol2012
21538547Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity.Proteins2011
19913036Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.J Mol Biol2010
20836087The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu.Protein Sci2010
20944232Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944231Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944230Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944228The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944225Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944224Structure of Bacteroides thetaiotaomicron BT2081 at 2.05⿿ÿ resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944223A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2⿿ÿ resolution.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944222Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944221The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944219The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944218Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944217Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944214Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944213The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944212Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944211The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45⿿ÿ resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944209Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944208The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944207Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944206The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20944205Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20122942Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair.J Mol Biol2010
19000695A structural basis for the regulatory inactivation of DnaA.J Mol Biol2009
19450606Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus.J Mol Biol2009
19567872Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes.J Biol Chem2009
19173316Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 A resolution.Proteins2009
19127588Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution.Proteins2009
19217401Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidase.Structure2009
18324683Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold.Proteins2008
17546672Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution.Proteins2007
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Collaborators

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 45
Joint Center for Structural Genomics
Co-authored papers 39
Merck & Co., Inc.
Co-authored papers 39
Rice University
Co-authored papers 38
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
Co-authored papers 38
Argonne National Laboratory
Co-authored papers 37
Celgene/Bristol-Myers Squibb Corporation
Co-authored papers 36
University of California Riverside
Co-authored papers 36
Joint Center for Structural Genomics
Co-authored papers 36
Bridge Institute, University of Southern California
Co-authored papers 36
University of California Riverside School of Medicine
Co-authored papers 34
University of California
Co-authored papers 34
Stanford University
Co-authored papers 34
Joint Center for Structural Genomics, University of California - San Diego
Co-authored papers 34
Stanford Cardiovascular Institute (L.W., Stanford University School of Medicine
Co-authored papers 34
Co-authored papers 34
University of Lucknow
Co-authored papers 34
Brown University
Co-authored papers 34
Co-authored papers 34
Co-authored papers 34
Cardiovascular Institute, Stanford University School of Medicine
Co-authored papers 34
Joint Center for Structural Genomics
Co-authored papers 34
Merck & Co., Inc.
Co-authored papers 34
Regeneron Pharmaceuticals, Inc.
Co-authored papers 34
Genomics Institute of the Novartis Research Foundation
Co-authored papers 34
University of California San Francisco
Co-authored papers 34
Joint Center for Structural Genomics, Sanford-Burnham Medical Research Institute
Co-authored papers 34
Institute of Science, Banaras Hindu University
Co-authored papers 33
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Co-authored papers 33