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Author Details

Raghavan Varadarajan
Indian Institute of Science
1985
157
37
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36382921Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics.Protein Sci2023
37861334Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity, and neutralization sensitivity.J Virol2023
38049728Molecular bases for strong phenotypic effects of single synonymous codon substitutions in the E. coli ccdB toxin gene.BMC Genomics2023
37880298Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants.NPJ Vaccines2023
37126530Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo.PLoS Pathog2023
37166011A CcdB toxin-derived peptide acts as a broad-spectrum antibacterial therapeutic in infected mice.EMBO Rep2023
36851560Neutralizing Efficacy of Encapsulin Nanoparticles against SARS-CoV2 Variants of Concern.Viruses2023
36714997Mutational scan inferred binding energetics and structure in intrinsically disordered protein CcdA.Protein Sci2023
35247389Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries.J Biol Chem2022
35762712Structural and functional determinants inferred from deep mutational scans.Protein Sci2022
35458530Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies against Delta and Omicron in Mice.Viruses2022
35720346Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens.Front Immunol2022
35357163Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis.J Bacteriol2022
35654847A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein.Nat Chem Biol2022
35872560Editorial overview: Engineering and design.Curr Opin Struct Biol2022
36275627Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region.Front Mol Biosci2022
36069948The High Mutational Sensitivity of ccdA Antitoxin Is Linked to Codon Optimality.Mol Biol Evol2022
35867800A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.Sci Immunol2022
36037221Mechanistic insights into global suppressors of protein folding defects.PLoS Genet2022
35127820Prediction of Residue-specific Contributions to Binding and Thermal Stability Using Yeast Surface Display.Front Mol Biosci2022
33154165Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment.J Biol Chem2021
33778004Prediction of Function Determining and Buried Residues Through Analysis of Saturation Mutagenesis Datasets.Front Mol Biosci2021
34946511Insight into OroxylinA-7-O-β-d-Glucuronide-Enriched Oroxylum indicum Bark Extract in Oral Cancer HSC-3 Cell Apoptotic Mechanism: Role of Mitochondrial Microenvironment.Molecules2021
34956193A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern.Front Immunol2021
34578291Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.Viruses2021
34260218Immunogenicity and Protective Efficacy of a Highly Thermotolerant, Trimeric SARS-CoV-2 Receptor Binding Domain Derivative.ACS Infect Dis2021
32537511VapBC22 toxin-antitoxin system from <i>Mycobacterium tuberculosis</i> is required for pathogenesis and modulation of host immune response.Sci Adv2020
33688632One-step sequence and structure-guided optimization of HIV-1 envelope gp140.Curr Res Struct Biol2020
33168755A facile method of mapping HIV-1 neutralizing epitopes using chemically masked cysteines and deep sequencing.Proc Natl Acad Sci U S A2020
33042034VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in <i>Mycobacterium tuberculosis</i>.Front Microbiol2020
32817217Probing the Structure of the HIV-1 Envelope Trimer Using Aspartate Scanning Mutagenesis.J Virol2020
32294467Mechanism of CcdA-Mediated Rejuvenation of DNA Gyrase.Structure2020
30615225Protein model discrimination attempts using mutational sensitivity, predicted secondary structure, and model quality information.Proteins2019
31018964Bioinformatic and mutational studies of related toxin-antitoxin pairs in <i>Mycobacterium tuberculosis</i> predict and identify key functional residues.J Biol Chem2019
30778066HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.Nat Commun2019
30777307CcdB at pH 4 Forms a Partially Unfolded State with a Dry Core.Biophys J2019
30993730Facile measurement of protein stability and folding kinetics using a nano differential scanning fluorimeter.Protein Sci2019
30843689Molecular Determinants of Temperature-Sensitive Phenotypes.Biochemistry2019
29237847A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques.J Virol2018
30220462Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles.Vaccine2018
29863853Isolation of an in Vitro Affinity-Matured, Thermostable "Headless" HA Stem Fragment That Binds Broadly Neutralizing Antibodies with High Affinity.Biochemistry2018
30120904Rv0474 is a copper-responsive transcriptional regulator that negatively regulates expression of RNA polymerase β subunit in Mycobacterium tuberculosis.FEBS J2018
30093409Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies.J Biol Chem2018
30004675Open and Closed Form of Maltose Binding Protein in Its Native and Molten Globule State As Studied by Electron Paramagnetic Resonance Spectroscopy.Biochemistry2018
29662494Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains.Front Immunol2018
29714013Rapid Mapping of Protein Binding Sites and Conformational Epitopes by Coupling Yeast Surface Display to Chemical Labeling and Deep Sequencing.Methods Mol Biol2018
29505936Insights into protein structure, stability and function from saturation mutagenesis.Curr Opin Struct Biol2018
27879316Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies.J Biol Chem2017
28332627Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library.Sci Rep2017
28132782Mapping Protein Binding Sites and Conformational Epitopes Using Cysteine Labeling and Yeast Surface Display.Structure2017
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Collaborators

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Co-authored papers 9
Genentech Inc.
Co-authored papers 7
Co-authored papers 6
Co-authored papers 6
Babraham Institute
Co-authored papers 5
University of California san francisco
Co-authored papers 5
Indian Institute of Science Education and Research Pune
Co-authored papers 4
Harvard University
Co-authored papers 3
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Indian Institute of Science
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
University of California San Francisco
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of Washington
Co-authored papers 1
University of Washington
Co-authored papers 1
University of California at San Francisco
Co-authored papers 1
Co-authored papers 1
University of Massachusetts Medical School
Co-authored papers 1
Co-authored papers 1
Weizmann Institute of Science
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Emory University
Co-authored papers 1