Author details

Full Name

Karine G Le Roch

Affiliation

ORCID

Career Start Year

2000

Papers

122

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36778461	A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in <i>Plasmodium vivax</i> Hypnozoites.	bioRxiv	2024
37293082	PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages.	bioRxiv	2023
37607941	Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum.	Nat Commun	2023
37708851	Sex determination and transmission: Leveraging genetic screens to reveal Plasmodium's secrets.		2023
37704606	Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages.		2023
36778504	ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages.		2023
37268002	Epigenetic Regulation and Chromatin Remodeling in Malaria Parasites.		2023
37391513	Small RNA sequencing of field Culex mosquitoes identifies patterns of viral infection and the mosquito immune response.	Sci Rep	2023
37121862	The role of long noncoding RNAs in malaria parasites.		2023
37064813	Autophagy in protists and their hosts: When, how and why?		2023
37055610	Babesia duncani multi-omics identifies virulence factors and drug targets.	Nat Microbiol	2023
36798191	Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation and chromosome segregation of sexual transmission stages.		2023
36730688	An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure.		2023
35087229	The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.	Nat Microbiol	2022
35900985	Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle.	PLoS Biology	2022
37200864	Decrypting the complexity of the human malaria parasite biology through systems biology approaches.		2022
35277503	Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum.	Nature Communications	2022
35136229	Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.	Nat Microbiol	2022
32797448	Strand-Specific RNA-Seq Applied to Malaria Samples.	Methods in Molecular Biology	2021
33539484	Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity?	PLoS Pathogens	2021
33656416	Identification and phylogenetic analysis of RNA binding domain abundant in apicomplexans or RAP proteins.	Microb Genom	2021
34342640	A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies.	J Exp Med	2021
34313988	Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq.	Methods in Molecular Biology	2021
34313981	Chromosomes Conformation Capture Coupled with Next-Generation Sequencing (Hi-C) in Plasmodium falciparum.	Methods in Molecular Biology	2021
32988634	Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites.	Trends in Genetics	2021
33425787	From Genes to Transcripts, a Tightly Regulated Journey in .	Frontiers in Cellular and Infection Microbiology	2020
32017676	The chromatin bound proteome of the human malaria parasite.	Microbial genomics	2020
32049018	Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.	Cell Rep	2020
32925902	The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.	PLoS Genet	2020
32501284	Real-time dynamics of NDC80 reveals unusual modes of chromosome segregation during parasite proliferation.	Journal of Cell Science	2020
32833084	Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.	Journal of Computer-Aided Molecular Design	2020
31409625	Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission.	Life Science Alliance	2019
31600347	Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.	PLoS Pathog	2019
31633082	Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites.	Epigenetics Insights	2019
30407670	The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts.	Plant J	2019
30009946	Unraveling the 3D genome of human malaria parasites.	Seminars in Cell and Developmental Biology	2019
30176236	Insights into the evolution and drug susceptibility of Babesia duncani from the sequence of its mitochondrial and apicoplast genomes.	International Journal for Parasitology	2019
31509524	Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features.	PLoS Computational Biology	2019
31220857	The role of epigenetics and chromatin structure in transcriptional regulation in malaria parasites.	Briefings in Functional Genomics	2019
31270921	Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20-Diisocyanoadociane.	Angewandte Chemie - International Edition	2019
30723152	Comparative 3D genome organization in apicomplexan parasites.	Proc Natl Acad Sci U S A	2019
29752147	Sex in Plasmodium falciparum: Silence Play between GDV1 and HP1.	Trends in Parasitology	2018
28720171	PacBio assembly of a Plasmodium knowlesi genome sequence with Hi-C correction and manual annotation of the SICAvar gene family.	Parasitology	2018
28712361	Plasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria.	Parasitology	2018
29765020	Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages.	Nature Communications	2018
28065669	The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.	Trends in Parasitology	2017
28337330	Antimalarial Properties of Simplified Kalihinol Analogues.	ACS Medicinal Chemistry Letters	2017
28531310	Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum.	Nucleic Acids Research	2017
26799652	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).	Autophagy	2016
26748697	Natural product-based synthesis of novel anti-infective isothiocyanate- and isoselenocyanate-functionalized amphilectane diterpenes.	Bioorganic and Medicinal Chemistry Letters	2016